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Metabolic and appetite hormone responses of hyperinsulinemic normoglycemic males to meals with varied macronutrient compositions

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dc.contributor.author El Khoury D.
dc.contributor.author Hwalla N.
dc.contributor.editor
dc.date 2010
dc.date.accessioned 2017-10-18T13:24:26Z
dc.date.available 2017-10-18T13:24:26Z
dc.date.issued 2010
dc.identifier 10.1159/000317343
dc.identifier.issn 2506807
dc.identifier.uri http://hdl.handle.net/10938/20272
dc.description.abstract Aims: The aim of this study was to investigate the appetite hormones and metabolic responses of hyperinsulinemic subjects to high-protein (HP) meals as compared to high-carbohydrate (HC) and high-fat (HF) meals. Design: Fifteen hyperinsulinemic normoglycemic men received, on 3 separate occasions, HP, HC, or HF meals in a randomized crossover design. Blood samples were collected before and after the ingestion of each meal. Postprandially, acylated ghrelin, PYY 3-36, insulin, glucose, and triglycerides were measured. Results: While the HC meal induced an acutely greater postprandial ghrelin decrease below baseline, the HP meal maintained this decline significantly more than the HF meal at 240 min. Postprandial PYY3-36 responses did not significantly vary with time and meal composition. Postprandial insulin and glucose peaks were significantly lower following the HP and HF meals in comparison to the HC meal, whereas triglyceride responses were significantly higher following the HF meal. Significant correlations, negative between acylated ghrelin and insulin and positive between PYY3-36 and insulin, were observed. Conclusions: In hyperinsulinemic normoglycemic men, HP meals ensure a longer-lasting suppression of circulating ghrelin levels and result in more favorable metabolic responses, characterized by a lower surge of postprandial insulin and glucose and a reduced postprandial triglyceride response, as compared to both HC and HF meals. Copyright © 2010 S. Karger AG, Basel.
dc.format.extent
dc.format.extent Pages: (59-67)
dc.language English
dc.publisher BASEL
dc.relation.ispartof Publication Name: Annals of Nutrition and Metabolism; Publication Year: 2010; Volume: 57; no. 1; Pages: (59-67);
dc.source Scopus
dc.title Metabolic and appetite hormone responses of hyperinsulinemic normoglycemic males to meals with varied macronutrient compositions
dc.type Article
dc.contributor.affiliation El Khoury, D., Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Hwalla, N., Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon, Faculty of Agricultural and Food Sciences, American University of Beirut, PO Box 11-0236, Riad El Solh, Beirut 1107-2020, Lebanon
dc.contributor.authorAddress El Khoury, D.; Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon; email: nahla@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Agricultural and Food Sciences; Department: Nutrition and Food Sciences;
dc.contributor.authorDepartment Nutrition and Food Sciences
dc.contributor.authorDivision
dc.contributor.authorEmail nahla@aub.edu.lb
dc.contributor.authorFaculty Faculty of Agricultural and Food Sciences
dc.contributor.authorInitials El Khoury, D
dc.contributor.authorInitials Hwalla, N
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Hwalla, N (reprint author), Amer Univ Beirut, Fac Agr and Food Sci, Dept Nutr and Food Sci, POB 11-0236,Riad El Solh, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut
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dc.description.citedCount 3
dc.description.citedTotWOSCount 4
dc.description.citedWOSCount 4
dc.format.extentCount 9
dc.identifier.articleNo
dc.identifier.coden ANUMD
dc.identifier.pubmedID 20714138
dc.identifier.scopusID 77955536126
dc.publisher.address ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
dc.relation.ispartOfISOAbbr Ann. Nutr. Metab.
dc.relation.ispartOfIssue 1
dc.relation.ispartofPubTitle Annals of Nutrition and Metabolism
dc.relation.ispartofPubTitleAbbr Ann. Nutr. Metab.
dc.relation.ispartOfVolume 57
dc.source.ID WOS:000281517200009
dc.type.publication Journal
dc.subject.otherAuthKeyword Carbohydrates
dc.subject.otherAuthKeyword fats
dc.subject.otherAuthKeyword ghrelin
dc.subject.otherAuthKeyword hyperinsulinemia
dc.subject.otherAuthKeyword peptide yy
dc.subject.otherAuthKeyword proteins
dc.subject.otherChemCAS Ghrelin, 258279-04-8, 304853-26-7
dc.subject.otherChemCAS glucose, 50-99-7, 84778-64-3
dc.subject.otherChemCAS insulin, 9004-10-8
dc.subject.otherChemCAS blood glucose
dc.subject.otherChemCAS dietary carbohydrates
dc.subject.otherChemCAS dietary fats
dc.subject.otherChemCAS dietary proteins
dc.subject.otherChemCAS ghrelin
dc.subject.otherChemCAS insulin, 11061-68-0
dc.subject.otherChemCAS peptide yy, 106388-42-5
dc.subject.otherChemCAS triglycerides
dc.subject.otherIndex Ghrelin
dc.subject.otherIndex glucose
dc.subject.otherIndex insulin
dc.subject.otherIndex peptide yy [3-36]
dc.subject.otherIndex triacylglycerol
dc.subject.otherIndex adult
dc.subject.otherIndex appetite
dc.subject.otherIndex article
dc.subject.otherIndex blood sampling
dc.subject.otherIndex carbohydrate diet
dc.subject.otherIndex clinical article
dc.subject.otherIndex clinical trial
dc.subject.otherIndex controlled clinical trial
dc.subject.otherIndex controlled study
dc.subject.otherIndex crossover procedure
dc.subject.otherIndex double blind procedure
dc.subject.otherIndex glucose blood level
dc.subject.otherIndex hormone blood level
dc.subject.otherIndex hormone response
dc.subject.otherIndex human
dc.subject.otherIndex hyperinsulinemia
dc.subject.otherIndex insulin blood level
dc.subject.otherIndex lipid diet
dc.subject.otherIndex macronutrient
dc.subject.otherIndex male
dc.subject.otherIndex metabolism
dc.subject.otherIndex priority journal
dc.subject.otherIndex protein intake
dc.subject.otherIndex randomized controlled trial
dc.subject.otherIndex triacylglycerol blood level
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex appetite regulation
dc.subject.otherIndex blood glucose
dc.subject.otherIndex dietary carbohydrates
dc.subject.otherIndex dietary fats
dc.subject.otherIndex dietary proteins
dc.subject.otherIndex ghrelin
dc.subject.otherIndex humans
dc.subject.otherIndex hyperinsulinism
dc.subject.otherIndex insulin
dc.subject.otherIndex male
dc.subject.otherIndex obesity
dc.subject.otherIndex peptide yy
dc.subject.otherIndex postprandial period
dc.subject.otherIndex triglycerides
dc.subject.otherIndex young adult
dc.subject.otherKeywordPlus Carbohydrate hypoenergetic diet
dc.subject.otherKeywordPlus polycystic-ovary-syndrome
dc.subject.otherKeywordPlus high-protein meals
dc.subject.otherKeywordPlus peptide-yy levels
dc.subject.otherKeywordPlus insulin-resistance
dc.subject.otherKeywordPlus food-intake
dc.subject.otherKeywordPlus plasma ghrelin
dc.subject.otherKeywordPlus body-weight
dc.subject.otherKeywordPlus amino-acids
dc.subject.otherKeywordPlus high-fat
dc.subject.otherWOS Endocrinology and Metabolism
dc.subject.otherWOS Nutrition and Dietetics
dc.identifier.doi http://dx.doi.org/10.1159/000317343


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