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High plasma leptin is not associated with higher bone mineral density in insulin-resistant premenopausal obese women

Show simple item record Samra R.A. Baba N.H. Torbay N. Dib L. Fuleihan G.E.-H.
dc.contributor.editor May-05 2017-10-18T13:24:31Z 2017-10-18T13:24:31Z 2005
dc.identifier 10.1210/jc.2004-2049
dc.description.abstract Obesity's protective effect on bone density may be mediated through increased muscle mass, fat mass, increased estrogen, and possibly insulin and leptin levels. To determine the impact of leptin and insulin on bone metabolism, we studied 48 obese normally cycling premenopausal women (age, 31 ± 10 yr; body mass index, 35.7 ± 5 kg-m2): 28 insulin resistant (ER) and 20 insulin sensitive (IS) by McAuley index. Anthropometric, body composition, and bone mineral density (BMD) measurements were made, and serum leptin, insulin, free testosterone, IGF-I, bone remodeling markers, and calciotropic hormones were measured. Anthropometric, lifestyle, and biochemical markers were similar in the two groups. Despite higher circulating insulin and leptin levels, IR subjects had similar mean values of serum osteocalcin but higher C-telopeptide (P = 0.052). They had similar BMD at all skeletal sites compared with IS subjects. In the IR group, fat mass but not lean mass, serum leptin, insulin, testosterone, and IGP-I levels correlated positively with hip and-or total-body bone density with R varying between 0.38 and 0.65; no correlations were observed at the spine. Conversely, in the IS group, lean mass, but not fat mass, and only IGF-I correlated with hip BMD-total-body bone mineral content. In conclusion, there is a dichotomy in the impact of body composition parameters and insulin and leptin levels on bone parameters in obese individuals. The interaction between the fat-related endocrine system and bone seems to be complex and may be modulated by local resistance to the putative protective effect of insulin and leptin on bone. Copyright © 2005 by The Endocrine Society.
dc.format.extent Pages: (2588-2594)
dc.language English
dc.publisher CHEVY CHASE
dc.relation.ispartof Publication Name: Journal of Clinical Endocrinology and Metabolism; Publication Year: 2005; Volume: 90; no. 5; Pages: (2588-2594);
dc.source Scopus
dc.title High plasma leptin is not associated with higher bone mineral density in insulin-resistant premenopausal obese women
dc.type Article
dc.contributor.affiliation Samra, R.A., Department of Nutrition and Food Science, American University of Beirut, Beirut, 113-6044, Lebanon
dc.contributor.affiliation Baba, N.H., Department of Nutrition and Food Science, American University of Beirut, Beirut, 113-6044, Lebanon
dc.contributor.affiliation Torbay, N., Department of Nutrition and Food Science, American University of Beirut, Beirut, 113-6044, Lebanon
dc.contributor.affiliation Dib, L., Calcium Metabolism and Osteoporosis Program, American University of Beirut, Beirut, 113-6044, Lebanon
dc.contributor.affiliation Fuleihan, G.E.-H., Department of Internal Medicine, American University of Beirut, Beirut, 113-6044, Lebanon, Calcium Metabolism and Osteoporosis Program, American University of Beirut Medical Center, Bliss Street, Beirut, 113-6044, Lebanon
dc.contributor.authorAddress Fuleihan, G.E.-H.; Calcium Metabolism and Osteoporosis Program, American University of Beirut Medical Center, Bliss Street, Beirut, 113-6044, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Agricultural and Food Sciences; Department: Nutrition and Food Sciences;
dc.contributor.authorDepartment Nutrition and Food Sciences
dc.contributor.authorFaculty Faculty of Agricultural and Food Sciences
dc.contributor.authorInitials Abou Samra, R
dc.contributor.authorInitials Baba, NH
dc.contributor.authorInitials Torbay, N
dc.contributor.authorInitials Dib, L
dc.contributor.authorInitials Fuleihan, GEH
dc.contributor.authorReprintAddress Fuleihan, GEH (reprint author), Amer Univ Beirut, Med Ctr, Dept Internal Med, Calcium Metab and Osteoporosis Program, Bliss St, Beirut 1136044, Lebanon.
dc.contributor.authorUniversity American University of Beirut
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dc.description.citedCount 18
dc.description.citedTotWOSCount 11
dc.description.citedWOSCount 11
dc.format.extentCount 7
dc.identifier.coden JCEMA
dc.identifier.pubmedID 15713708
dc.identifier.scopusID 18844439138
dc.publisher.address 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
dc.relation.ispartOfISOAbbr J. Clin. Endocrinol. Metab.
dc.relation.ispartOfIssue 5
dc.relation.ispartofPubTitle Journal of Clinical Endocrinology and Metabolism
dc.relation.ispartofPubTitleAbbr J. Clin. Endocrinol. Metab.
dc.relation.ispartOfVolume 90
dc.source.ID WOS:000228914200016
dc.type.publication Journal
dc.subject.otherChemCAS Insulin, 9004-10-8
dc.subject.otherChemCAS osteocalcin, 136461-80-8
dc.subject.otherChemCAS somatomedin c, 67763-96-6
dc.subject.otherChemCAS testosterone, 58-22-0
dc.subject.otherChemCAS collagen, 9007-34-5
dc.subject.otherChemCAS insulin-like growth factor i, 67763-96-6
dc.subject.otherChemCAS leptin
dc.subject.otherIndex Biochemical marker
dc.subject.otherIndex carboxy terminal telopeptide
dc.subject.otherIndex estrogen
dc.subject.otherIndex insulin
dc.subject.otherIndex leptin
dc.subject.otherIndex osteocalcin
dc.subject.otherIndex somatomedin c
dc.subject.otherIndex testosterone
dc.subject.otherIndex adult
dc.subject.otherIndex anthropometry
dc.subject.otherIndex article
dc.subject.otherIndex body fat
dc.subject.otherIndex body mass
dc.subject.otherIndex bone density
dc.subject.otherIndex bone metabolism
dc.subject.otherIndex bone mineral
dc.subject.otherIndex clinical article
dc.subject.otherIndex correlation analysis
dc.subject.otherIndex estrogen blood level
dc.subject.otherIndex female
dc.subject.otherIndex hip
dc.subject.otherIndex human
dc.subject.otherIndex insulin blood level
dc.subject.otherIndex insulin resistance
dc.subject.otherIndex insulin sensitivity
dc.subject.otherIndex lifestyle
dc.subject.otherIndex muscle mass
dc.subject.otherIndex obesity
dc.subject.otherIndex premenopause
dc.subject.otherIndex priority journal
dc.subject.otherIndex spine
dc.subject.otherIndex testosterone blood level
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex bone density
dc.subject.otherIndex bone remodeling
dc.subject.otherIndex collagen
dc.subject.otherIndex female
dc.subject.otherIndex humans
dc.subject.otherIndex insulin resistance
dc.subject.otherIndex insulin-like growth factor i
dc.subject.otherIndex leptin
dc.subject.otherIndex middle aged
dc.subject.otherIndex obesity
dc.subject.otherIndex premenopause
dc.subject.otherKeywordPlus Dependent diabetes-mellitus
dc.subject.otherKeywordPlus healthy postmenopausal women
dc.subject.otherKeywordPlus polycystic-ovary-syndrome
dc.subject.otherKeywordPlus body-composition
dc.subject.otherKeywordPlus serum leptin
dc.subject.otherKeywordPlus fat mass
dc.subject.otherKeywordPlus biochemical markers
dc.subject.otherKeywordPlus vertebral fractures
dc.subject.otherKeywordPlus growth-factors
dc.subject.otherKeywordPlus cell-function
dc.subject.otherWOS Endocrinology and Metabolism

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