AUB ScholarWorks

Association of H. pylori Infection with Insulin Resistance and Metabolic Syndrome Among Lebanese Adults

Show simple item record

dc.contributor.author Naja F.
dc.contributor.author Nasreddine L.
dc.contributor.author Hwalla N.
dc.contributor.author Moghames P.
dc.contributor.author Shoaib H.
dc.contributor.author Fatfat M.
dc.contributor.author Sibai A.
dc.contributor.author Gali-Muhtasib H.
dc.contributor.editor
dc.date 2012
dc.date.accessioned 2017-10-18T13:24:33Z
dc.date.available 2017-10-18T13:24:33Z
dc.date.issued 2012
dc.identifier 10.1111/j.1523-5378.2012.00970.x
dc.identifier.issn 10834389
dc.identifier.uri http://hdl.handle.net/10938/20299
dc.description.abstract Background: Several epidemiological studies proposed an association between Helicobacter pylori ( H. pylori) infection with insulin resistance (IR) and metabolic syndrome (MetS). However, up to date there is no conclusive evidence regarding this association. Objectives: To investigate the prevalence and correlates of H. pylori infection among Lebanese adults and to evaluate its association with IR and MetS. Materials and Methods: Stored blood samples of adults participating in the national Nutrition and Non-Communicable Diseases Risk factors survey conducted in Lebanon were used for this study (n = 308). H. pylori-specific immunoglobulin G antibody titers were measured by ELISA. Data available included, in addition to anthropometric measurements, sociodemographic and lifestyle characteristics, blood pressure, and biochemical indices (serum insulin, HDL, LDL, TAG, glucose). A HOMA -IR level was used to assess insulin resistance. The International Diabetes Federation criteria were used to classify study participants with MetS. Results: The prevalence of H. pylori infection in the study sample was 52percent (95percent CI, 46.43-57.57). A higher crowding index was associated with a 50percent increase in the odds of infection (OR, 1.41; CI, 1.08-2.27). Blood pressure, waist circumference, serum HDL, LDL, TAG, and glucose levels were comparable between H. pylori positive and negative subjects. The odds of IR and MetS were not significantly different between the two groups. Conclusion: Prevalence of H. pylori infection in Lebanon is comparable to other developing countries. Furthermore, our findings suggested no association of H. pylori infection with IR or MetS. Eradication of H. pylori infection to prevent IR or MetS is not warranted. © 2012 Blackwell Publishing Ltd.
dc.format.extent
dc.format.extent Pages: (444-451)
dc.language English
dc.publisher HOBOKEN
dc.relation.ispartof Publication Name: Helicobacter; Publication Year: 2012; Volume: 17; no. 6; Pages: (444-451);
dc.source Scopus
dc.title Association of H. pylori Infection with Insulin Resistance and Metabolic Syndrome Among Lebanese Adults
dc.type Article
dc.contributor.affiliation Naja, F., Department of Biology, American University of Beirut, Beirut, Lebanon, Members of the Public Health And Nutrition (PHAN), Research Group at the American University of Beirut, Po Box 11-0236, Riad El-Solh Beirut 1107-2020, Lebanon
dc.contributor.affiliation Nasreddine, L., Department of Biology, American University of Beirut, Beirut, Lebanon, Members of the Public Health And Nutrition (PHAN), Research Group at the American University of Beirut, Po Box 11-0236, Riad El-Solh Beirut 1107-2020, Lebanon
dc.contributor.affiliation Hwalla, N., Department of Biology, American University of Beirut, Beirut, Lebanon, Members of the Public Health And Nutrition (PHAN), Research Group at the American University of Beirut, Po Box 11-0236, Riad El-Solh Beirut 1107-2020, Lebanon
dc.contributor.affiliation Moghames, P., Department of Biology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Shoaib, H., Department of Biology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Fatfat, M., Department of Epidemiology and Population Health, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Sibai, A., Department of Epidemiology and Population Health, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Gali-Muhtasib, H., Department of Epidemiology and Population Health, American University of Beirut, Beirut, Lebanon
dc.contributor.authorAddress Gali-Muhtasib, H.; Department of Nutrition and Food Sciences, American University of Beirut, Beirut, Lebanon; email: amro@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Agricultural and Food Sciences; Department: Nutrition and Food Sciences;
dc.contributor.authorDepartment Nutrition and Food Sciences
dc.contributor.authorDivision
dc.contributor.authorEmail amro@aub.edu.lb
dc.contributor.authorFaculty Faculty of Agricultural and Food Sciences
dc.contributor.authorInitials Naja, F
dc.contributor.authorInitials Nasreddine, L
dc.contributor.authorInitials Hwalla, N
dc.contributor.authorInitials Moghames, P
dc.contributor.authorInitials Shoaib, H
dc.contributor.authorInitials Fatfat, M
dc.contributor.authorInitials Sibai, A
dc.contributor.authorInitials Gali-Muhtasib, H
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Gali-Muhtasib, H (reprint author), Amer Univ Beirut, Dept Biol, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut
dc.description.cited Sibai Abla-Mehio, 2008, CVD Prevention and Control, V3, DOI 10.1016-j.precon.2007.06.002; Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161-CIRCULATIONAHA.109.192644; Aslan M, 2006, WORLD J GASTROENTERO, V12, P6865; Aydemir S, 2005, DIGEST DIS SCI, V50, P2090, DOI 10.1007-s10620-005-3012-z; Baum A, 1978, HUMAN RESPONSE CROWD, P3; Beckman JA, 2002, JAMA-J AM MED ASSOC, V287, P2570, DOI 10.1001-jama.287.19.2570; Begue RE, 1999, PEDIATRICS, V103, DOI 10.1542-peds.103.6.e83; Borai A, 2011, BMC MED RES METHODOL, V11, DOI 10.1186-1471-2288-11-158; Central Administration for Statistics and UNDP, 2006, LIV COND HOUS NAT SU, P114; Chedid R, 2009, METABOLISM, V58, P746, DOI 10.1016-j.metabol.2008.11.014; Christodoulou DK, 2011, EUR J INTERN MED, V22, P191, DOI 10.1016-j.ejim.2010.11.010; Danesh J, 1998, BRIT MED J, V316, P1130; deFoneska A, 2010, CURR OPIN GASTROEN, V26, P604, DOI 10.1097-MOG.0b013e32833f1222; Dore MP, 2000, NUTRITION, V16, P407, DOI 10.1016-S0899-9007(00)00267-7; Eshraghian A, 2009, DIGEST DIS SCI, V54, P1966, DOI 10.1007-s10620-008-0557-7; FORMAN D, 1991, BRIT MED J, V302, P1302; Freedman J., 1975, CROWDING BEHAV, P1; Frenck RW, 2003, MICROBES INFECT, V5, P705, DOI 10.1016-S1286-4579(03)00112-6; Gen R, 2010, SOUTH MED J, V103, P190, DOI 10.1097-SMJ.0b013e3181cf373f; Gillum RF, 2004, J NATL MED ASSOC, V96, P1470; Goh KL, 2011, HELICOBACTER, V16, P1, DOI 10.1111-j.1523-5378.2011.00874.x; Gunji T, 2008, AM J GASTROENTEROL, V103, P3005, DOI 10.1111-j.1572-0241.2008.02151.x; Gunji T, 2009, HELICOBACTER, V14, P144, DOI 10.1111-j.1523-5378.2009.00705.x; Haffner SM, 1997, AM J MED, V103, P152; Helfand M, 2009, ANN INTERN MED, V151, P496; Huang BS, 2011, DIGEST DIS SCI, V56, P109, DOI 10.1007-s10620-010-1274-6; Hussein NR, 2010, WORLD J GASTROENTERO, V16, P3226, DOI 10.3748-wjg.v16.i26.3226; Kalaajieh W K, 2000, Sante, V10, P31; Longo-Mbenza B, 2007, INT J CARDIOL, V121, P229, DOI 10.1016-j.ijcard.2006.12.003; Lu Ye-Hsu, 2002, Kaohsiung J Med Sci, V18, P266; Manolakis A, 2007, HELICOBACTER, V12, P287, DOI 10.1111-j.1523-5378.2007.00511.x; MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007-BF00280883; Melki IS, 2004, J EPIDEMIOL COMMUN H, V58, P476, DOI 10.1136-jech.2003.012690; Murray LJ, 1997, INT J EPIDEMIOL, V26, P880, DOI 10.1093-ije-26.4.880; Naja F, 2011, EUR J NUTR, DOI [10.1007-500394-011-0291-3, DOI 10.1007-500394-011-0291-3]; Naja F, 2007, CAN J GASTROENTEROL, V21, P501; Naous Amal, 2007, J Med Liban, V55, P138; Schottker B, 2012, ATHEROSCLEROSIS, V220, P569, DOI 10.1016-j.atherosclerosis.2011.11.029; Sharara AI, 2006, DIGEST LIVER DIS, V38, P829, DOI 10.1016-j.dld.2006.06.040; Steinbach G, 1999, ANN INTERN MED, V131, P88; Suzuki H, 2011, HELICOBACTER, V16, P65, DOI 10.1111-j.1523-5378.2011.00883.x; Uday J., 1987, PSYCHOL CONSEQUENCES, P15; Wang Shao-zhen, 2009, Zhonghua Yi Xue Za Zhi, V89, P958; Woodward M, 2000, J CLIN EPIDEMIOL, V53, P175, DOI 10.1016-S0895-4356(99)00171-7; WOTHERSPOON AC, 1991, LANCET, V338, P1175, DOI 10.1016-0140-6736(91)92035-Z
dc.description.citedCount 7
dc.description.citedTotWOSCount 8
dc.description.citedWOSCount 8
dc.format.extentCount 8
dc.identifier.articleNo
dc.identifier.coden HELIF
dc.identifier.pubmedID 23066847
dc.identifier.scopusID 84867702976
dc.publisher.address 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
dc.relation.ispartOfISOAbbr Helicobacter
dc.relation.ispartOfIssue 6
dc.relation.ispartofPubTitle Helicobacter
dc.relation.ispartofPubTitleAbbr Helicobacter
dc.relation.ispartOfVolume 17
dc.source.ID WOS:000310319900006
dc.type.publication Journal
dc.subject.otherAuthKeyword Cardio-vascular risk factor
dc.subject.otherAuthKeyword epidemiology
dc.subject.otherAuthKeyword prevalence rate
dc.subject.otherChemCAS Glucose, 50-99-7, 84778-64-3
dc.subject.otherChemCAS insulin, 9004-10-8
dc.subject.otherChemCAS antibodies, bacterial
dc.subject.otherChemCAS immunoglobulin g
dc.subject.otherIndex Glucose
dc.subject.otherIndex high density lipoprotein cholesterol
dc.subject.otherIndex immunoglobulin g antibody
dc.subject.otherIndex insulin
dc.subject.otherIndex low density lipoprotein cholesterol
dc.subject.otherIndex triacylglycerol
dc.subject.otherIndex adult
dc.subject.otherIndex anthropometric parameters
dc.subject.otherIndex antibody titer
dc.subject.otherIndex article
dc.subject.otherIndex blood pressure
dc.subject.otherIndex blood sampling
dc.subject.otherIndex chemical analysis
dc.subject.otherIndex cholesterol blood level
dc.subject.otherIndex crowding
dc.subject.otherIndex disease association
dc.subject.otherIndex enzyme linked immunosorbent assay
dc.subject.otherIndex female
dc.subject.otherIndex glucose blood level
dc.subject.otherIndex helicobacter infection
dc.subject.otherIndex helicobacter pylori
dc.subject.otherIndex human
dc.subject.otherIndex insulin blood level
dc.subject.otherIndex insulin resistance
dc.subject.otherIndex lebanon
dc.subject.otherIndex lifestyle
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex metabolic syndrome x
dc.subject.otherIndex priority journal
dc.subject.otherIndex seroprevalence
dc.subject.otherIndex socioeconomics
dc.subject.otherIndex triacylglycerol blood level
dc.subject.otherIndex waist circumference
dc.subject.otherIndex adult
dc.subject.otherIndex antibodies, bacterial
dc.subject.otherIndex cross-sectional studies
dc.subject.otherIndex enzyme-linked immunosorbent assay
dc.subject.otherIndex female
dc.subject.otherIndex helicobacter infections
dc.subject.otherIndex helicobacter pylori
dc.subject.otherIndex humans
dc.subject.otherIndex immunoglobulin g
dc.subject.otherIndex insulin resistance
dc.subject.otherIndex lebanon
dc.subject.otherIndex male
dc.subject.otherIndex metabolic syndrome x
dc.subject.otherIndex middle aged
dc.subject.otherIndex prevalence
dc.subject.otherKeywordPlus Coronary-heart-disease
dc.subject.otherKeywordPlus helicobacter-pylori
dc.subject.otherKeywordPlus risk-factors
dc.subject.otherKeywordPlus diabetes-mellitus
dc.subject.otherKeywordPlus japanese population
dc.subject.otherKeywordPlus gastric lymphoma
dc.subject.otherKeywordPlus epidemiology
dc.subject.otherKeywordPlus atherosclerosis
dc.subject.otherKeywordPlus inflammation
dc.subject.otherKeywordPlus prevalence
dc.subject.otherWOS Gastroenterology and Hepatology
dc.subject.otherWOS Microbiology
dc.identifier.doi http://dx.doi.org/10.1111/j.1523-5378.2012.00970.x


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


Browse

My Account