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Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria

Show simple item record Smriga M. Ghosh S. Mouneimne Y. Pellett P.L. Scrimshaw N.S.
dc.contributor.editor 2004 2017-10-18T13:27:38Z 2017-10-18T13:27:38Z 2004
dc.identifier 10.1073/pnas.0402550101
dc.identifier.issn 278424
dc.description.abstract Lysine is a limiting amino acid in diets based on wheat as the staple. In experimental animals, prolonged dietary lysine inadequacy increases stress-induced anxiety. If observed in humans, such a result would have a strong implication for the relationship between nutrition and communal quality of life and mental health. As part of a 3-month randomized double-blind study, we tested whether lysine fortification of wheat reduces anxiety and stress response in family members in poor Syrian communities consuming wheat asa staple food. In the lysine-fortified group, the plasma cortisol response to the blood drawing as a cause of stress was reduced in females, as was sympathetic arousal in males as measured by skin conductance. Lysine fortification also significantly reduced chronic anxiety as measured by the trait anxiety inventory in males. These results suggest that some stress responses in economically weak populations consuming cereal-based diets can be improved with lysine fortification.
dc.format.extent Pages: (8285-8288)
dc.language English
dc.publisher WASHINGTON
dc.relation.ispartof Publication Name: Proceedings of the National Academy of Sciences of the United States of America; Publication Year: 2004; Volume: 101; no. 22; Pages: (8285-8288);
dc.source Scopus
dc.title Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria
dc.type Article
dc.contributor.affiliation Smriga, M., Institute of Life Sciences, Ajinomoto Co., Inc., 210-8681 Kawasaki, Japan
dc.contributor.affiliation Ghosh, S., Intl. Ctr. for Agricultural Research, Tel Hadya, Aleppo, Syrian Arab Republic, Food and Nutrition Program, United Nations University, Boston, MA 02111, United States
dc.contributor.affiliation Mouneimne, Y., Central Research Science Laboratory, American University of Beirut, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Pellett, P.L., Department of Nutrition, University of Massachusetts, Amherst, MA 01003-9282, United States
dc.contributor.affiliation Scrimshaw, N.S., Food and Nutrition Program, United Nations University, Boston, MA 02111, United States
dc.contributor.authorAddress Scrimshaw, N.S.; Food and Nutrition Program, United Nations University, Boston, MA 02111, United States; email:
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Agricultural and Food Sciences; Department: FAFS;
dc.contributor.authorDepartment FAFS
dc.contributor.Faculty Faculty of Agricultural and Food Sciences
dc.contributor.authorInitials Smriga, M
dc.contributor.authorInitials Ghosh, S
dc.contributor.authorInitials Mouneimne, Y
dc.contributor.authorInitials Pellett, PL
dc.contributor.authorInitials Scrimshaw, NS
dc.contributor.authorReprintAddress Smriga, M (reprint author), United Nations Univ, Food and Nutr Program, Boston, MA 02111 USA.
dc.contributor.authorUniversity American University of Beirut
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dc.description.citedCount 17
dc.description.citedTotWOSCount 19
dc.description.citedWOSCount 16
dc.format.extentCount 4
dc.identifier.coden PNASA
dc.identifier.pubmedID 15159538
dc.identifier.scopusID 2942622060
dc.publisher.address 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
dc.relation.ispartOfISOAbbr Proc. Natl. Acad. Sci. U. S. A.
dc.relation.ispartOfIssue 22
dc.relation.ispartofPubTitle Proceedings of the National Academy of Sciences of the United States of America
dc.relation.ispartofPubTitleAbbr Proc. Natl. Acad. Sci. U. S. A.
dc.relation.ispartOfVolume 101
dc.source.ID WOS:000221831800008
dc.type.publication Journal
dc.subject.otherChemCAS Hydrocortisone, 50-23-7
dc.subject.otherChemCAS lysine, 56-87-1, 6899-06-5, 70-54-2
dc.subject.otherChemCAS hydrocortisone, 50-23-7
dc.subject.otherChemCAS lysine, 56-87-1
dc.subject.otherIndex Hydrocortisone
dc.subject.otherIndex lysine
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex amino acid metabolism
dc.subject.otherIndex anxiety
dc.subject.otherIndex article
dc.subject.otherIndex cereal
dc.subject.otherIndex child
dc.subject.otherIndex clinical trial
dc.subject.otherIndex controlled clinical trial
dc.subject.otherIndex controlled study
dc.subject.otherIndex diet supplementation
dc.subject.otherIndex double blind procedure
dc.subject.otherIndex family
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex hydrocortisone blood level
dc.subject.otherIndex lowest income group
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex malnutrition
dc.subject.otherIndex priority journal
dc.subject.otherIndex quality of life
dc.subject.otherIndex randomized controlled trial
dc.subject.otherIndex stress
dc.subject.otherIndex sympathetic tone
dc.subject.otherIndex syrian arab republic
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex animals
dc.subject.otherIndex anxiety
dc.subject.otherIndex bread
dc.subject.otherIndex child
dc.subject.otherIndex diet
dc.subject.otherIndex double-blind method
dc.subject.otherIndex economics
dc.subject.otherIndex female
dc.subject.otherIndex food, fortified
dc.subject.otherIndex humans
dc.subject.otherIndex hydrocortisone
dc.subject.otherIndex lysine
dc.subject.otherIndex male
dc.subject.otherIndex quality of life
dc.subject.otherIndex questionnaires
dc.subject.otherIndex residence characteristics
dc.subject.otherIndex stress, psychological
dc.subject.otherIndex syria
dc.subject.otherIndex triticum
dc.subject.otherIndex animalia
dc.subject.otherIndex triticum aestivum
dc.subject.otherKeywordPlus Balance technique
dc.subject.otherKeywordPlus acid
dc.subject.otherKeywordPlus rats
dc.subject.otherKeywordPlus requirements
dc.subject.otherKeywordPlus receptor
dc.subject.otherKeywordPlus supplementation
dc.subject.otherKeywordPlus evolutionary
dc.subject.otherKeywordPlus disorders
dc.subject.otherKeywordPlus cortisol
dc.subject.otherKeywordPlus single
dc.subject.otherWOS Multidisciplinary Sciences

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