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Current prevalence of hepatitis delta virus (HDV) infection and the range of HDV genotypes in Lebanon

Show simple item record Ramia S. El-zaatari M. Sharara A.I. Ramlawi F. Farhat B.
dc.contributor.editor Aug-2007 2017-10-18T13:38:21Z 2017-10-18T13:38:21Z 2007
dc.identifier 10.1017/S0950268806007643
dc.identifier.issn 09502688
dc.description.abstract Recently the prevalence of hepatitis B virus (HBV) genotypes and the association between these genotypes and the clinical status of HBV-infected patients were recently investigated in the Lebanese population. The aim of the additional study reported here was to determine the current prevalence of hepatitis delta virus (HDV) infection and the range of HDV genotypes in this Lebanese population. Two hundred and fifty-eight HBsAg-positive patients (107 asymptomatic blood donors, 92 with chronic hepatitis, 24 with cirrhosis, 15 with hepatocellular carcinoma, 20 patients on haemodialysis) from ten medical centers in Lebanon were tested for antibody to hepatitis D virus (anti-HDV). Those testing positive were analysed further for HDV-RNA and for genotyping by reverse transcriptase-polymerase chain reaction (RT-PCR) and restriction fragment length polymorphism (RFLP). Three samples (1.2percent) were anti-HDV positive and out of these, only one was HDV-RNA positive (0.6percent) and was analysed as HDV genotype I. Our results point to a low endemicity of HDV in the Lebanese population which is in sharp contrast to data reported from Lebanon 20 years ago and to the situation in neighbouring Arab and non-Arab countries in the Mediterranean region. HDV genotype I seems to be the predominant genotype in Lebanon and the Middle East. © 2006 Cambridge University Press.
dc.format.extent Pages: (959-962)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Epidemiology and Infection; Publication Year: 2007; Volume: 135; no. 6; Pages: (959-962);
dc.source Scopus
dc.title Current prevalence of hepatitis delta virus (HDV) infection and the range of HDV genotypes in Lebanon
dc.type Article
dc.contributor.affiliation Ramia, S., Faculty of Health Sciences, Department of Medical Laboratory Technology, American University of Beirut, PO Box 11-0236, Riad El Soloh 1107-2020 Beirut, Lebanon
dc.contributor.affiliation El-zaatari, M., Department of Laboratory Medicine, Hamoud Hospital, Saida, Lebanon
dc.contributor.affiliation Sharara, A.I., Faculty of Medicine, Department of Gastroenterology, American University of Beirut, PO Box 11-0236, Riad El Soloh 1107-2020 Beirut, Lebanon
dc.contributor.affiliation Ramlawi, F., Faculty of Health Sciences, Department of Medical Laboratory Technology, American University of Beirut, PO Box 11-0236, Riad El Soloh 1107-2020 Beirut, Lebanon
dc.contributor.affiliation Farhat, B., Department of Gastroenterology, Rasoul Al-Azam Hospital, Beirut, Lebanon
dc.contributor.authorAddress Ramia, S.; Faculty of Health Sciences, American University of Beirut, PO Box 11-0236, Riad El Soloh 1107-2020 Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Health Sciences; Department: Medical Laboratory Sciences Program;
dc.contributor.authorDepartment Medical Laboratory Sciences Program
dc.contributor.faculty Faculty of Health Sciences
dc.contributor.authorInitials Ramia, S
dc.contributor.authorInitials El-Zaatari, M
dc.contributor.authorInitials Sharara, AI
dc.contributor.authorInitials Ramlawi, F
dc.contributor.authorInitials Farhat, B
dc.contributor.authorReprintAddress Ramia, S (reprint author), American Univ, Fac Hlth Sci, PO Box 11-0236,Riad El Soloh, Beirut 1107 2020, Lebanon.
dc.contributor.authorUniversity American University of Beirut
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dc.description.citedCount 13
dc.description.citedTotWOSCount 13
dc.description.citedWOSCount 12
dc.format.extentCount 4
dc.identifier.coden EPINE
dc.identifier.pubmedID 17176498
dc.identifier.scopusID 34748919446
dc.publisher.address 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
dc.relation.ispartOfISOAbbr Epidemiol. Infect.
dc.relation.ispartOfIssue 6
dc.relation.ispartofPubTitle Epidemiology and Infection
dc.relation.ispartofPubTitleAbbr Epidemiol. Infect.
dc.relation.ispartOfVolume 135
dc.source.ID WOS:000249150500011
dc.type.publication Journal
dc.subject.otherIndex hepatitis antibody
dc.subject.otherIndex hepatitis B surface antigen
dc.subject.otherIndex virus RNA
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex blood donor
dc.subject.otherIndex chronic hepatitis
dc.subject.otherIndex delta agent hepatitis
dc.subject.otherIndex endemic disease
dc.subject.otherIndex female
dc.subject.otherIndex genotype
dc.subject.otherIndex hemodialysis
dc.subject.otherIndex Hepatitis delta virus
dc.subject.otherIndex human
dc.subject.otherIndex infection rate
dc.subject.otherIndex Lebanon
dc.subject.otherIndex liver cell carcinoma
dc.subject.otherIndex liver cirrhosis
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex Middle East
dc.subject.otherIndex nonhuman
dc.subject.otherIndex prevalence
dc.subject.otherIndex restriction fragment length polymorphism
dc.subject.otherIndex reverse transcription polymerase chain reaction
dc.subject.otherIndex Southern Europe
dc.subject.otherIndex genetics
dc.subject.otherIndex isolation and purification
dc.subject.otherIndex virology
dc.subject.otherIndex Adult
dc.subject.otherIndex Female
dc.subject.otherIndex Genotype
dc.subject.otherIndex Hepatitis D
dc.subject.otherIndex Hepatitis Delta Virus
dc.subject.otherIndex Humans
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Male
dc.subject.otherIndex Prevalence
dc.subject.otherKeywordPlus FRAGMENT-LENGTH-POLYMORPHISM
dc.subject.otherKeywordPlus PHYLOGENETIC ANALYSIS
dc.subject.otherKeywordPlus ENDEMIC AREA
dc.subject.otherKeywordPlus TAIWAN
dc.subject.otherKeywordPlus SEROEPIDEMIOLOGY
dc.subject.otherKeywordPlus EPIDEMIOLOGY
dc.subject.otherWOS Public, Environmental and Occupational Health
dc.subject.otherWOS Infectious Diseases

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