Current prevalence of hepatitis delta virus (HDV) infection and the range of HDV genotypes in Lebanon

Ramia S.; El-zaatari M.; Sharara A.I.; Ramlawi F.; Farhat B.

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dc.contributor.author	Ramia S.
dc.contributor.author	El-zaatari M.
dc.contributor.author	Sharara A.I.
dc.contributor.author	Ramlawi F.
dc.contributor.author	Farhat B.
dc.contributor.editor
dc.date	Aug-2007
dc.date.accessioned	2017-10-18T13:38:21Z
dc.date.available	2017-10-18T13:38:21Z
dc.date.issued	2007
dc.identifier	10.1017/S0950268806007643
dc.identifier.isbn
dc.identifier.issn	09502688
dc.identifier.uri	http://hdl.handle.net/10938/20712
dc.description.abstract	Recently the prevalence of hepatitis B virus (HBV) genotypes and the association between these genotypes and the clinical status of HBV-infected patients were recently investigated in the Lebanese population. The aim of the additional study reported here was to determine the current prevalence of hepatitis delta virus (HDV) infection and the range of HDV genotypes in this Lebanese population. Two hundred and fifty-eight HBsAg-positive patients (107 asymptomatic blood donors, 92 with chronic hepatitis, 24 with cirrhosis, 15 with hepatocellular carcinoma, 20 patients on haemodialysis) from ten medical centers in Lebanon were tested for antibody to hepatitis D virus (anti-HDV). Those testing positive were analysed further for HDV-RNA and for genotyping by reverse transcriptase-polymerase chain reaction (RT-PCR) and restriction fragment length polymorphism (RFLP). Three samples (1.2percent) were anti-HDV positive and out of these, only one was HDV-RNA positive (0.6percent) and was analysed as HDV genotype I. Our results point to a low endemicity of HDV in the Lebanese population which is in sharp contrast to data reported from Lebanon 20 years ago and to the situation in neighbouring Arab and non-Arab countries in the Mediterranean region. HDV genotype I seems to be the predominant genotype in Lebanon and the Middle East. © 2006 Cambridge University Press.
dc.format.extent
dc.format.extent	Pages: (959-962)
dc.language	English
dc.publisher	NEW YORK
dc.relation.ispartof	Publication Name: Epidemiology and Infection; Publication Year: 2007; Volume: 135; no. 6; Pages: (959-962);
dc.relation.ispartofseries
dc.relation.uri
dc.source	Scopus
dc.subject.other
dc.title	Current prevalence of hepatitis delta virus (HDV) infection and the range of HDV genotypes in Lebanon
dc.type	Article
dc.contributor.affiliation	Ramia, S., Faculty of Health Sciences, Department of Medical Laboratory Technology, American University of Beirut, PO Box 11-0236, Riad El Soloh 1107-2020 Beirut, Lebanon
dc.contributor.affiliation	El-zaatari, M., Department of Laboratory Medicine, Hamoud Hospital, Saida, Lebanon
dc.contributor.affiliation	Sharara, A.I., Faculty of Medicine, Department of Gastroenterology, American University of Beirut, PO Box 11-0236, Riad El Soloh 1107-2020 Beirut, Lebanon
dc.contributor.affiliation	Ramlawi, F., Faculty of Health Sciences, Department of Medical Laboratory Technology, American University of Beirut, PO Box 11-0236, Riad El Soloh 1107-2020 Beirut, Lebanon
dc.contributor.affiliation	Farhat, B., Department of Gastroenterology, Rasoul Al-Azam Hospital, Beirut, Lebanon
dc.contributor.authorAddress	Ramia, S.; Faculty of Health Sciences, American University of Beirut, PO Box 11-0236, Riad El Soloh 1107-2020 Beirut, Lebanon; email: sramia@aub.edu.lb
dc.contributor.authorCorporate	University: American University of Beirut; Faculty: Faculty of Health Sciences; Department: Medical Laboratory Sciences Program;
dc.contributor.authorDepartment	Medical Laboratory Sciences Program
dc.contributor.authorDivision
dc.contributor.authorEmail	sramia@aub.edu.lb
dc.contributor.faculty	Faculty of Health Sciences
dc.contributor.authorInitials	Ramia, S
dc.contributor.authorInitials	El-Zaatari, M
dc.contributor.authorInitials	Sharara, AI
dc.contributor.authorInitials	Ramlawi, F
dc.contributor.authorInitials	Farhat, B
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress	Ramia, S (reprint author), American Univ, Fac Hlth Sci, PO Box 11-0236,Riad El Soloh, Beirut 1107 2020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity	American University of Beirut
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dc.description.citedCount	13
dc.description.citedTotWOSCount	13
dc.description.citedWOSCount	12
dc.format.extentCount	4
dc.identifier.articleNo
dc.identifier.coden	EPINE
dc.identifier.pubmedID	17176498
dc.identifier.scopusID	34748919446
dc.identifier.url
dc.publisher.address	32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr	Epidemiol. Infect.
dc.relation.ispartOfIssue	6
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle	Epidemiology and Infection
dc.relation.ispartofPubTitleAbbr	Epidemiol. Infect.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume	135
dc.source.ID	WOS:000249150500011
dc.type.publication	Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS
dc.subject.otherIndex	hepatitis antibody
dc.subject.otherIndex	hepatitis B surface antigen
dc.subject.otherIndex	virus RNA
dc.subject.otherIndex	adult
dc.subject.otherIndex	article
dc.subject.otherIndex	blood donor
dc.subject.otherIndex	chronic hepatitis
dc.subject.otherIndex	delta agent hepatitis
dc.subject.otherIndex	endemic disease
dc.subject.otherIndex	female
dc.subject.otherIndex	genotype
dc.subject.otherIndex	hemodialysis
dc.subject.otherIndex	Hepatitis delta virus
dc.subject.otherIndex	human
dc.subject.otherIndex	infection rate
dc.subject.otherIndex	Lebanon
dc.subject.otherIndex	liver cell carcinoma
dc.subject.otherIndex	liver cirrhosis
dc.subject.otherIndex	major clinical study
dc.subject.otherIndex	male
dc.subject.otherIndex	Middle East
dc.subject.otherIndex	nonhuman
dc.subject.otherIndex	prevalence
dc.subject.otherIndex	restriction fragment length polymorphism
dc.subject.otherIndex	reverse transcription polymerase chain reaction
dc.subject.otherIndex	Southern Europe
dc.subject.otherIndex	genetics
dc.subject.otherIndex	isolation and purification
dc.subject.otherIndex	virology
dc.subject.otherIndex	Adult
dc.subject.otherIndex	Female
dc.subject.otherIndex	Genotype
dc.subject.otherIndex	Hepatitis D
dc.subject.otherIndex	Hepatitis Delta Virus
dc.subject.otherIndex	Humans
dc.subject.otherIndex	Lebanon
dc.subject.otherIndex	Male
dc.subject.otherIndex	Prevalence
dc.subject.otherKeywordPlus	FRAGMENT-LENGTH-POLYMORPHISM
dc.subject.otherKeywordPlus	PHYLOGENETIC ANALYSIS
dc.subject.otherKeywordPlus	ENDEMIC AREA
dc.subject.otherKeywordPlus	TAIWAN
dc.subject.otherKeywordPlus	SEROEPIDEMIOLOGY
dc.subject.otherKeywordPlus	EPIDEMIOLOGY
dc.subject.otherWOS	Public, Environmental and Occupational Health
dc.subject.otherWOS	Infectious Diseases

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