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The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8+ T cell responses

Show simple item record Melhem N.M. Smith K.N. Huang X.-L. Colleton B.A. Jiang W. Mailliard R.B. Mullins J.I. Rinaldo C.R.
dc.contributor.editor 2014 2017-10-18T13:38:22Z 2017-10-18T13:38:22Z 2014
dc.identifier 10.1016/j.virol.2013.10.015
dc.identifier.issn 00426822
dc.description.abstract It is unclear if HIV-1 variants lose the ability to prime naïve CD8+ cytotoxic T lymphocytes (CTL) during progressive, untreated infection. We conducted a comprehensive longitudinal analysis of viral evolution and its impact on primary and memory CD8+ T cell responses pre-seroconversion (SC), post-SC, and during combination antiretroviral therapy (cART). Memory T cell responses targeting autologous virus variants reached a nadir by 8 years post-SC with development of AIDS, followed by a transient enhancement of anti-HIV-1 CTL responses upon initiation of cART. We show broad and high magnitude primary T cell responses to late variants in pre-SC T cells, comparable to primary anti-HIV-1 responses induced in T cells from uninfected persons. Despite evolutionary changes, CD8+ T cells could still be primed to HIV-1 variants. Hence, vaccination against late, mutated epitopes could be successful in enhancing primary reactivity of T cells for control of the residual reservoir of HIV-1 during cART. © 2013.
dc.format.extent Pages: (34-48)
dc.language English
dc.publisher SAN DIEGO
dc.relation.ispartof Publication Name: Virology; Publication Year: 2014; Pages: (34-48);
dc.source Scopus
dc.title The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8+ T cell responses
dc.type Article
dc.contributor.affiliation Melhem, N.M., American University of Beirut, Faculty of Health Sciences, Medical Laboratory Sciences Program, 11-0236 Riad El Solh, 1107-2020 Beirut, Lebanon
dc.contributor.affiliation Smith, K.N., University of Pittsburgh, School of Medicine, Department of Microbiology and Molecular Genetics, Pittsburgh, PA 15213, United States
dc.contributor.affiliation Huang, X.-L., University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261, United States
dc.contributor.affiliation Colleton, B.A., Pennsylvania State University, M.S. Hershey Medical Center College of Medicine, Department of Public Health Sciences, Hershey, PA 17033, United States
dc.contributor.affiliation Jiang, W., University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261, United States
dc.contributor.affiliation Mailliard, R.B., University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261, United States
dc.contributor.affiliation Mullins, J.I., University of Washington, School of Medicine, Department of Microbiology, Seattle, WA 98195-8070, United States
dc.contributor.affiliation Rinaldo, C.R., University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261, United States
dc.contributor.authorAddress Rinaldo, C.R.; University of Pittsburgh Graduate School of Public Health, Department of Pathology, 130 DeSoto StreetA419 Crabtree Hall, Pittsburgh, PA 15261, United States; email:
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Health Sciences; Department: Medical Laboratory Sciences Program;
dc.contributor.authorDepartment Medical Laboratory Sciences Program
dc.contributor.faculty Faculty of Health Sciences
dc.contributor.authorInitials Melhem, NM
dc.contributor.authorInitials Smith, KN
dc.contributor.authorInitials Huang, XL
dc.contributor.authorInitials Colleton, BA
dc.contributor.authorInitials Jiang, WM
dc.contributor.authorInitials Mailliard, RB
dc.contributor.authorInitials Mullins, JI
dc.contributor.authorInitials Rinaldo, CR
dc.contributor.authorReprintAddress Rinaldo, CR (reprint author), Univ Pittsburgh, Grad Sch Publ Hlth, Dept Pathol, 130 DeSoto St,A419 Crabtree Hall, Pittsburgh, PA 15261 USA.
dc.contributor.authorUniversity American University of Beirut
dc.description.cited Addo MM, 2003, J VIROL, V77, P2081, DOI 10.1128-JVI.77.3.2081-2092.2003; Allen TM, 2000, NATURE, V407, P386; Allen TM, 2004, J VIROL, V78, P7069, DOI 10.1128-JVI.78.13.7069-7078.2004; Allen TM, 2002, J VIROL, V76, P10507, DOI 10.1128-JVI.76.20.10507-10511.2002; Appay V, 2008, NAT MED, V14, P623, DOI 10.1038-nm.f.1774; Baker BM, 2009, EXPERT OPIN BIOL TH, V9, P55, DOI 10.1517-14712590802571928 ; Bangham CRM, 2009, EUR J IMMUNOL, V39, P1700, DOI 10.1002-eji.200939451; Barouch DH, 2010, ANNU REV MED, V61, P153, DOI; Barouch DH, 2003, J VIROL, V77, P8729, DOI 10.1128-JVI.77.16.8729-8735.2003; Berger CT, 2011, J VIROL, V85, P9334, DOI 10.1128-JVI.00460-11; Bihl F, 2006, J IMMUNOL, V176, P4094; Borrow P, 1997, NAT MED, V3, P205, DOI 10.1038-nm0297-205; Buchli R, 2005, BIOCHEMISTRY-US, V44, P12491, DOI 10.1021-bi050255v; Buseyne F, 2001, INT IMMUNOL, V13, P941, DOI 10.1093-intimm-13.7.941; Casazza JP, 2005, J VIROL, V79, P3653, DOI 10.1128-JVI.79.6.3653-3663.2005; Chen HB, 2012, NAT IMMUNOL, V13, P691, DOI 10.1038-ni.2342; Colleton BA, 2009, J VIROL, V83, P6288, DOI 10.1128-JVI.02611-08; Corbeau P, 2011, BLOOD, V117, P5582, DOI 10.1182-blood-2010-12-322453; Corey L, 2009, AIDS, V23, P3, DOI 10.1097-QAD.0b013e32830e6d6d; Davenport MP, 2007, CURR OPIN IMMUNOL, V19, P294, DOI 10.1016-j.coi.2007.04.001; Deeks SG, 2007, IMMUNITY, V27, P406, DOI 10.1016-j.immuni.2007.08.010; Detels R, 2012, PUBLIC HEALTH, V126, P196, DOI 10.1016-j.puhe.2011.11.013; Draenert R, 2004, J EXP MED, V199, P905, DOI 10.1084-jem.20031982; Fan Z, 2007, CLIN VACCINE IMMUNOL, V14, P1127, DOI 10.1128-CVI.00141-07; Frahm N, 2004, J VIROL, V78, P2187, DOI 10.1128-JVI.78.5.2187-2200.2004; GIORGI JV, 1990, CLIN IMMUNOL IMMUNOP, V55, P173, DOI 10.1016-0090-1229(90)90096-9; Goulder PJR, 2008, NAT REV IMMUNOL, V8, P619, DOI 10.1038-nri2357; Hoof I, 2009, IMMUNOGENETICS, V61, P1, DOI 10.1007-s00251-008-0341-z; Huang XL, 2008, J LEUKOCYTE BIOL, V83, P1530, DOI 10.1189-jlb.1107795; Janbazian L, 2012, J IMMUNOL, V188, P1156, DOI 10.4049-jimmunol.1102610; Jones NA, 2004, J EXP MED, V200, P1243, DOI 10.1084-jem.20040511; Kalams SA, 1999, J VIROL, V73, P6721; KASLOW RA, 1987, AM J EPIDEMIOL, V126, P310; Kiepiela P, 2007, NAT MED, V13, P46, DOI 10.1038-nm1520; KOUP RA, 1994, J VIROL, V68, P4650; Ladell K, 2013, IMMUNITY, V38, P425, DOI 10.1016-j.immuni.2012.11.021; Leslie AJ, 2004, NAT MED, V10, P282, DOI 10.1038-nm992; Liu JY, 2009, NATURE, V457, P87, DOI 10.1038-nature07469; Liu Y, 2011, PLOS ONE, V6, DOI 10.1371-journal.pone.0015639; Liu Y, 2007, J VIROL, V81, P12179, DOI 10.1128-JVI.01277-07; Liu Y, 2006, J VIROL, V80, P9519, DOI 10.1128-JVI.00575-06; Malaspina Angela, 2011, Vaccine, V29, P4647, DOI 10.1016-j.vaccine.2011.04.035; Malhotra U, 2007, J VIROL, V81, P5225, DOI 10.1128-JVI.02564-06; McElrath MJ, 2008, LANCET, V372, P1894, DOI 10.1016-S0140-6736(08)61592-5; Nielsen M, 2007, PLOS ONE, V2, DOI 10.1371-journal.pone.0000796; O'Connor DH, 2002, NAT MED, V8, P493, DOI 10.1038-nm0502-493; Pandrea I, 2011, PLOS PATHOG, V7, DOI 10.1371-journal.ppat.1002170; PARKER KC, 1994, J IMMUNOL, V152, P163; Price DA, 2004, IMMUNITY, V21, P793, DOI 10.1016-j.immuni.2004.10.010; Prlic M, 2007, CURR OPIN IMMUNOL, V19, P315, DOI 10.1016-j.coi.2007.04.010; Reynolds MR, 2008, J EXP MED, V205, P2537, DOI 10.1084-jem.20081524; Rinaldo CR, 2009, J INTERN MED, V265, P138, DOI 10.1111-j.1365-2796.2008.02047.x; Rinaldo CR, 2000, J VIROL, V74, P4127, DOI 10.1128-JVI.74.9.4127-4138.2000; Rolland M, 2008, PLOS ONE, V3, DOI 10.1371-journal.pone.0001424; Rosario M, 2010, EUR J IMMUNOL, V40, P1973, DOI 10.1002-eji.201040344; Saez-Cirion A, 2007, P NATL ACAD SCI USA, V104, P6776, DOI 10.1073-pnas.0611244104; SCHENKER EL, 1993, CYTOMETRY, V14, P307, DOI 10.1002-cyto.990140311; Schmitz JE, 1999, SCIENCE, V283, P857, DOI 10.1126-science.283.5403.857; Schneider Eileen, 2008, Morbidity and Mortality Weekly Report, V57, P1; Shankarappa R, 1999, J VIROL, V73, P10489; Shin H, 2007, J EXP MED, V204, P941, DOI 10.1084-jem.20061937; Shriner D, 2004, GENETICS, V167, P1573, DOI 10.1534-genetics.103.023382; Tenzer S, 2009, NAT IMMUNOL, V10, P636, DOI 10.1038-ni.1728; Turnbull EL, 2009, J IMMUNOL, V182, P7131, DOI 10.4049-jimmunol.0803658; van Bockel DJ, 2011, J IMMUNOL, V186, P359, DOI 10.4049-jimmunol.1001807; Vezys V, 2006, J EXP MED, V203, P2263, DOI 10.1084-jem.20060995; Wherry EJ, 2004, P NATL ACAD SCI USA, V101, P16004, DOI 10.1073-pnas.0407192101; Yokomaku Y, 2004, J VIROL, V78, P1324, DOI 10.1128-JVI.78.3.1324-1332.2004; Yusim S., 2004, HIV IMMUNOLOGY HIV S, P25; Zehn D, 2009, NATURE, V458, P211, DOI 10.1038-nature07657
dc.description.citedTotWOSCount 2
dc.description.citedWOSCount 1
dc.format.extentCount 15
dc.identifier.coden VIRLA
dc.identifier.pubmedID 24503065
dc.identifier.scopusID 84890810921
dc.publisher.address 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
dc.relation.ispartofFundingAgency R01-AI-40388, NIH, National Institutes of Health
dc.relation.ispartofFundingAgency R37-AI-41870, NIH, National Institutes of Health
dc.relation.ispartofFundingAgency U01-AI-35041, NIH, National Institutes of Health
dc.relation.ispartofFundingAgency T32-AI065380, NIH, National Institutes of Health
dc.relation.ispartOfISOAbbr Virology
dc.relation.ispartofPubTitle Virology
dc.relation.ispartofPubTitleAbbr Virology
dc.source.ID WOS:000331485500005
dc.type.publication Journal
dc.subject.otherAuthKeyword Autologous viral variants
dc.subject.otherAuthKeyword CART
dc.subject.otherAuthKeyword HIV-1
dc.subject.otherAuthKeyword Memory T cell responses
dc.subject.otherAuthKeyword Primary T cell responses
dc.subject.otherChemCAS abacavir, 136470-78-5, 188062-50-2
dc.subject.otherChemCAS efavirenz, 154598-52-4
dc.subject.otherChemCAS lamivudine, 134678-17-4, 134680-32-3
dc.subject.otherChemCAS nelfinavir, 159989-64-7, 159989-65-8
dc.subject.otherChemCAS saquinavir, 127779-20-8, 149845-06-7
dc.subject.otherChemCAS zidovudine, 30516-87-1
dc.subject.otherIndex abacavir
dc.subject.otherIndex antiretrovirus agent
dc.subject.otherIndex CD8 antigen
dc.subject.otherIndex efavirenz
dc.subject.otherIndex efavirenz plus emtricitabine plus tenofovir disoproxil
dc.subject.otherIndex epitope
dc.subject.otherIndex lamivudine
dc.subject.otherIndex nelfinavir
dc.subject.otherIndex saquinavir
dc.subject.otherIndex zidovudine
dc.subject.otherIndex acquired immune deficiency syndrome
dc.subject.otherIndex adult
dc.subject.otherIndex antigen specificity
dc.subject.otherIndex article
dc.subject.otherIndex CD8+ T lymphocyte
dc.subject.otherIndex genetic conservation
dc.subject.otherIndex human
dc.subject.otherIndex human cell
dc.subject.otherIndex Human immunodeficiency virus 1
dc.subject.otherIndex Human immunodeficiency virus 1 infection
dc.subject.otherIndex immunoreactivity
dc.subject.otherIndex memory T lymphocyte
dc.subject.otherIndex nonhuman
dc.subject.otherIndex priority journal
dc.subject.otherIndex seroconversion
dc.subject.otherIndex Autologous viral variants
dc.subject.otherIndex cART
dc.subject.otherIndex HIV-1
dc.subject.otherIndex Memory T cell responses
dc.subject.otherIndex Primary T cell responses
dc.subject.otherIndex Adult
dc.subject.otherIndex Anti-HIV Agents
dc.subject.otherIndex CD8-Positive T-Lymphocytes
dc.subject.otherIndex Cohort Studies
dc.subject.otherIndex Epitopes, T-Lymphocyte
dc.subject.otherIndex Evolution, Molecular
dc.subject.otherIndex Histocompatibility Antigens Class I
dc.subject.otherIndex HIV Infections
dc.subject.otherIndex HIV-1
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex T-Lymphocytes
dc.subject.otherIndex Viral Proteins
dc.subject.otherKeywordPlus MULTICENTER AIDS COHORT
dc.subject.otherKeywordPlus HIV-1 INFECTION
dc.subject.otherKeywordPlus LYMPHOCYTE ESCAPE
dc.subject.otherKeywordPlus FUNCTIONAL-AVIDITY
dc.subject.otherKeywordPlus PEPTIDE-BINDING
dc.subject.otherKeywordPlus DENDRITIC CELLS
dc.subject.otherKeywordPlus IMMUNE CONTROL
dc.subject.otherKeywordPlus ANTIGEN
dc.subject.otherKeywordPlus VACCINE
dc.subject.otherWOS Virology

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