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The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8+ T cell responses

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dc.contributor.author Melhem N.M.
dc.contributor.author Smith K.N.
dc.contributor.author Huang X.-L.
dc.contributor.author Colleton B.A.
dc.contributor.author Jiang W.
dc.contributor.author Mailliard R.B.
dc.contributor.author Mullins J.I.
dc.contributor.author Rinaldo C.R.
dc.contributor.editor
dc.date 2014
dc.date.accessioned 2017-10-18T13:38:22Z
dc.date.available 2017-10-18T13:38:22Z
dc.date.issued 2014
dc.identifier 10.1016/j.virol.2013.10.015
dc.identifier.isbn
dc.identifier.issn 00426822
dc.identifier.uri http://hdl.handle.net/10938/20721
dc.description.abstract It is unclear if HIV-1 variants lose the ability to prime naïve CD8+ cytotoxic T lymphocytes (CTL) during progressive, untreated infection. We conducted a comprehensive longitudinal analysis of viral evolution and its impact on primary and memory CD8+ T cell responses pre-seroconversion (SC), post-SC, and during combination antiretroviral therapy (cART). Memory T cell responses targeting autologous virus variants reached a nadir by 8 years post-SC with development of AIDS, followed by a transient enhancement of anti-HIV-1 CTL responses upon initiation of cART. We show broad and high magnitude primary T cell responses to late variants in pre-SC T cells, comparable to primary anti-HIV-1 responses induced in T cells from uninfected persons. Despite evolutionary changes, CD8+ T cells could still be primed to HIV-1 variants. Hence, vaccination against late, mutated epitopes could be successful in enhancing primary reactivity of T cells for control of the residual reservoir of HIV-1 during cART. © 2013.
dc.format.extent
dc.format.extent Pages: (34-48)
dc.language English
dc.publisher SAN DIEGO
dc.relation.ispartof Publication Name: Virology; Publication Year: 2014; Pages: (34-48);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8+ T cell responses
dc.type Article
dc.contributor.affiliation Melhem, N.M., American University of Beirut, Faculty of Health Sciences, Medical Laboratory Sciences Program, 11-0236 Riad El Solh, 1107-2020 Beirut, Lebanon
dc.contributor.affiliation Smith, K.N., University of Pittsburgh, School of Medicine, Department of Microbiology and Molecular Genetics, Pittsburgh, PA 15213, United States
dc.contributor.affiliation Huang, X.-L., University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261, United States
dc.contributor.affiliation Colleton, B.A., Pennsylvania State University, M.S. Hershey Medical Center College of Medicine, Department of Public Health Sciences, Hershey, PA 17033, United States
dc.contributor.affiliation Jiang, W., University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261, United States
dc.contributor.affiliation Mailliard, R.B., University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261, United States
dc.contributor.affiliation Mullins, J.I., University of Washington, School of Medicine, Department of Microbiology, Seattle, WA 98195-8070, United States
dc.contributor.affiliation Rinaldo, C.R., University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261, United States
dc.contributor.authorAddress Rinaldo, C.R.; University of Pittsburgh Graduate School of Public Health, Department of Pathology, 130 DeSoto StreetA419 Crabtree Hall, Pittsburgh, PA 15261, United States; email: rinaldo@pitt.edu
dc.contributor.authorCorporate University: American University of Beirut; Faculty: Faculty of Health Sciences; Department: Medical Laboratory Sciences Program;
dc.contributor.authorDepartment Medical Laboratory Sciences Program
dc.contributor.authorDivision
dc.contributor.authorEmail rinaldo@pitt.edu
dc.contributor.authorFaculty Faculty of Health Sciences
dc.contributor.authorInitials Melhem, NM
dc.contributor.authorInitials Smith, KN
dc.contributor.authorInitials Huang, XL
dc.contributor.authorInitials Colleton, BA
dc.contributor.authorInitials Jiang, WM
dc.contributor.authorInitials Mailliard, RB
dc.contributor.authorInitials Mullins, JI
dc.contributor.authorInitials Rinaldo, CR
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Rinaldo, CR (reprint author), Univ Pittsburgh, Grad Sch Publ Hlth, Dept Pathol, 130 DeSoto St,A419 Crabtree Hall, Pittsburgh, PA 15261 USA.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut
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dc.description.citedCount
dc.description.citedTotWOSCount 2
dc.description.citedWOSCount 1
dc.format.extentCount 15
dc.identifier.articleNo
dc.identifier.coden VIRLA
dc.identifier.pubmedID 24503065
dc.identifier.scopusID 84890810921
dc.identifier.url
dc.publisher.address 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency R01-AI-40388, NIH, National Institutes of Health
dc.relation.ispartofFundingAgency R37-AI-41870, NIH, National Institutes of Health
dc.relation.ispartofFundingAgency U01-AI-35041, NIH, National Institutes of Health
dc.relation.ispartofFundingAgency T32-AI065380, NIH, National Institutes of Health
dc.relation.ispartOfISOAbbr Virology
dc.relation.ispartOfIssue
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Virology
dc.relation.ispartofPubTitleAbbr Virology
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume
dc.source.ID WOS:000331485500005
dc.type.publication Journal
dc.subject.otherAuthKeyword Autologous viral variants
dc.subject.otherAuthKeyword CART
dc.subject.otherAuthKeyword HIV-1
dc.subject.otherAuthKeyword Memory T cell responses
dc.subject.otherAuthKeyword Primary T cell responses
dc.subject.otherChemCAS abacavir, 136470-78-5, 188062-50-2
dc.subject.otherChemCAS efavirenz, 154598-52-4
dc.subject.otherChemCAS lamivudine, 134678-17-4, 134680-32-3
dc.subject.otherChemCAS nelfinavir, 159989-64-7, 159989-65-8
dc.subject.otherChemCAS saquinavir, 127779-20-8, 149845-06-7
dc.subject.otherChemCAS zidovudine, 30516-87-1
dc.subject.otherIndex abacavir
dc.subject.otherIndex antiretrovirus agent
dc.subject.otherIndex CD8 antigen
dc.subject.otherIndex efavirenz
dc.subject.otherIndex efavirenz plus emtricitabine plus tenofovir disoproxil
dc.subject.otherIndex epitope
dc.subject.otherIndex lamivudine
dc.subject.otherIndex nelfinavir
dc.subject.otherIndex saquinavir
dc.subject.otherIndex zidovudine
dc.subject.otherIndex acquired immune deficiency syndrome
dc.subject.otherIndex adult
dc.subject.otherIndex antigen specificity
dc.subject.otherIndex article
dc.subject.otherIndex CD8+ T lymphocyte
dc.subject.otherIndex genetic conservation
dc.subject.otherIndex human
dc.subject.otherIndex human cell
dc.subject.otherIndex Human immunodeficiency virus 1
dc.subject.otherIndex Human immunodeficiency virus 1 infection
dc.subject.otherIndex immunoreactivity
dc.subject.otherIndex memory T lymphocyte
dc.subject.otherIndex nonhuman
dc.subject.otherIndex priority journal
dc.subject.otherIndex seroconversion
dc.subject.otherIndex Autologous viral variants
dc.subject.otherIndex cART
dc.subject.otherIndex HIV-1
dc.subject.otherIndex Memory T cell responses
dc.subject.otherIndex Primary T cell responses
dc.subject.otherIndex Adult
dc.subject.otherIndex Anti-HIV Agents
dc.subject.otherIndex CD8-Positive T-Lymphocytes
dc.subject.otherIndex Cohort Studies
dc.subject.otherIndex Epitopes, T-Lymphocyte
dc.subject.otherIndex Evolution, Molecular
dc.subject.otherIndex Histocompatibility Antigens Class I
dc.subject.otherIndex HIV Infections
dc.subject.otherIndex HIV-1
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex T-Lymphocytes
dc.subject.otherIndex Viral Proteins
dc.subject.otherKeywordPlus MULTICENTER AIDS COHORT
dc.subject.otherKeywordPlus ACTIVE ANTIRETROVIRAL THERAPY
dc.subject.otherKeywordPlus HIV-1 INFECTION
dc.subject.otherKeywordPlus LYMPHOCYTE ESCAPE
dc.subject.otherKeywordPlus FUNCTIONAL-AVIDITY
dc.subject.otherKeywordPlus PEPTIDE-BINDING
dc.subject.otherKeywordPlus DENDRITIC CELLS
dc.subject.otherKeywordPlus IMMUNE CONTROL
dc.subject.otherKeywordPlus ANTIGEN
dc.subject.otherKeywordPlus VACCINE
dc.subject.otherWOS Virology


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