Abstract:
This issue of Hematology-Oncology Clinics, edited by Dr. Ali Taher, focuses on thalassemia. Topics include, but are not limited to, molecular basis and genetic modifiers; evolving spectrum of epidemiology; clinical classification; Ineffective erythropoiesis, anemia and iron overload; hypercoagulability and vascular disease; clinical complications and their management; transfusion and iron chelation therapy; hematopoietic stem cell transplantation in thalassemia; gene therapy and genome editing; emerging therapies; quality of life; advances in understanding pathophysiology and treatment of fertility, pregnancy, and prenatal diagnosis in thalassemia; and MRI for iron overload.