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When should a brain mri be performed in children with new-onset seizures? results of a large prospective trial

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dc.contributor.author Hourani, Roula G.
dc.contributor.author Nasreddine, Wassim M.
dc.contributor.author Dirani, Maya M.
dc.contributor.author Hmaimess, Ghassan
dc.contributor.author Sabbagh, Sandra El
dc.contributor.author El-Tourjuman, Oulfat
dc.contributor.author Wazne, Jaafar
dc.contributor.author Toufaili, Hassan A.
dc.contributor.author Al-Arab, Natally
dc.contributor.author El Dassouki, Mohamad
dc.contributor.author Beydoun, Ahmad A.
dc.date.accessioned 2025-01-24T11:41:11Z
dc.date.available 2025-01-24T11:41:11Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10938/29696
dc.description.abstract BACKGROUND AND PURPOSE: There is a paucity of data regarding the incidence of structural brain lesions in children with new-onset unprovoked seizures. Our aim was to determine the frequencies and types of epileptogenic lesions detected on a dedicated epilepsy protocol MR imaging according to age group, the presence of developmental delay, and the number and types of seizures. MATERIALS AND METHODS: Consecutive children between 6 months and 18 years of age with new-onset unprovoked seizures were included. The frequencies and types of epileptogenic lesions were determined and then stratified according to sex, age groups, the presence of developmental delay, and the number and types of seizures at presentation. Multivariate analysis was used to identify variables significantly associated with the presence of epileptogenic lesions. RESULTS: One thousand children were included. An epileptogenic lesion was identified in 26%, with malformations of cortical development being the most common lesion (32%), followed by hypoxic-ischemic injury (20%) and vascular etiologies (16%). Univariate analysis showed a significant increase in the frequency of epileptogenic lesions with decreasing age, the presence of developmental delay, and the number and types of seizures at presentation. The presence of developmental delay and seizure type at presentation remained significant in a multivariate analysis. CONCLUSIONS: We documented a relatively high rate of epileptogenic lesions in children with new-onset seizures, with the presence of developmental delay and specific seizure types being associated with a higher likelihood of detecting an epileptogenic lesion on neuroimaging. This study fulfills the requirements of the study design recommended by the Practice Committee of the American Academy of Neurology, and we hope that our results will assist the relevant societies and committees in formulating neuroimaging guidelines for children with new-onset seizures. © 2021 American Society of Neuroradiology. All rights reserved.
dc.language.iso en
dc.publisher American Society of Neuroradiology
dc.relation.ispartof American Journal of Neuroradiology
dc.source Scopus
dc.subject Brain
dc.subject Child
dc.subject Humans
dc.subject Magnetic resonance imaging
dc.subject Neuroimaging
dc.subject Prospective studies
dc.subject Seizures
dc.subject Adolescent
dc.subject Agyria
dc.subject Arachnoid cyst
dc.subject Article
dc.subject Astrocytoma
dc.subject Atonic seizure
dc.subject Brain arteriovenous malformation
dc.subject Brain tumor
dc.subject Childhood absence epilepsy
dc.subject Clinical protocol
dc.subject Controlled study
dc.subject Cortical dysplasia
dc.subject Developmental delay
dc.subject Disease classification
dc.subject Encephalomalacia
dc.subject Epidermoid cyst
dc.subject Epileptic focus
dc.subject Female
dc.subject Fluid-attenuated inversion recovery imaging
dc.subject Focal epilepsy
dc.subject Gliosis
dc.subject Groups by age
dc.subject Hamartoma
dc.subject Heterotopia
dc.subject Holoprosencephaly
dc.subject Human
dc.subject Hypoxic ischemic encephalopathy
dc.subject Infant
dc.subject Intellectual impairment
dc.subject Leukodystrophy
dc.subject Major clinical study
dc.subject Male
dc.subject Metabolic disorder
dc.subject Microgyria
dc.subject Multiple malformation syndrome
dc.subject Myoclonus
dc.subject Neurofibromatosis
dc.subject Nuclear magnetic resonance imaging
dc.subject Prospective study
dc.subject Psychomotor development
dc.subject Seizure
dc.subject Septooptic dysplasia
dc.subject Tonic clonic seizure
dc.subject Tonic seizure
dc.subject Tuberous sclerosis
dc.subject Diagnostic imaging
dc.title When should a brain mri be performed in children with new-onset seizures? results of a large prospective trial
dc.type Article
dc.contributor.department Diagnostic Radiology
dc.contributor.department Neurology
dc.contributor.faculty Faculty of Medicine (FM)
dc.contributor.institution American University of Beirut
dc.identifier.doi https://doi.org/10.3174/ajnr.A7193
dc.identifier.pmid 34244128
dc.identifier.eid 2-s2.0-85114868537


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