Laryngopharyngeal symptoms in patients with asthma: A cross-sectional controlled study

Abstract

Objective: To examine the frequency and severity of laryngopharyngeal symptoms in asthmatic patients. The role of laryngopharyngeal reflux disease as a co-morbid disease to asthma has not been previously reported. Subjects and Method: Seventy-two subjects, 36 asthmatics and 36 controls were included in this study. Demographic data included age, gender, status of asthma, use of steroid inhalers, smoking and history of allergy. Pulmonary function test was reported in 13 subjects. The evaluation consisted of filling the Reflux Symptom Index (RSI) described by Belafsky etal. The total score, frequency and average score of each laryngopharyngeal symptom was computed in both groups. Results: The mean age of patients was 46.61±17.59 years with a female to male ratio of 2.3:1. Twenty patients were using steroid inhalers. Close to one third were smokers (30.6%) and 55.6% had allergic rhinitis. Thirty-six percent had controlled asthma vs 64% were uncontrolled. The mean of the total RSI was significantly higher in patients compared with controls (12.03±8.3 vs 6.64±6.08, P value<0.05). In the asthmatic group, 15 subjects had a positive RSI compared with only 4 in the control group (P value of 0.003). There was a significant difference in the prevalence and means of four laryngopharyngeal symptoms in patients vs controls. Conclusion: Laryngopharyngeal reflux disease is more prevalent and more severe in patients with asthma vs controls. © 2016 John Wiley & Sons Ltd.