Plasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock
Loading...
Date
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor and Francis Ltd
Abstract
Objective: To compare plasma levels of F-actin, G-actin and thymosin beta 4 (TB4) in humans with septic shock, noninfectious systemic inflammatory response syndrome (SIRS) and healthy controls.Results: F-actin was significantly elevated in septic shock as compared with noninfectious SIRS and healthy controls. G-actin levels were greatest in the noninfectious SIRS group but significantly elevated in septic shock as compared with healthy controls. TB4 was not detectable in the septic shock or noninfectious SIRS group above the assays lowest detection range (78 ng/ml).Conclusions: F-actin is significantly elevated in patients with septic shock as compared with noninfectious SIRS. F-actin and the F:G-actin ratio are potential biomarkers for the diagnosis of septic shock. © 2016 Taylor & Francis.
Description
Keywords
Actin, Actin binding protein, Coronary artery bypass graft, F-actin, G-actin, Septic shock, Thymosin beta 4, Actins, Adult, Aged, Biomarkers, Enzyme-linked immunosorbent assay, Female, Humans, Male, Middle aged, Roc curve, Shock, septic, Systemic inflammatory response syndrome, Thymosin, F actin, G actin, Thymosin beta4, Biological marker, Thymosin beta(4), Acute liver failure, Apache, Area under the curve, Article, Clinical article, Cohort analysis, Controlled study, Human, Intensive care unit, Length of stay, Mortality, Protein blood level, Blood, Enzyme linked immunosorbent assay, Receiver operating characteristic