Fibroscan and low-density lipoprotein as determinants of severe liver fibrosis in diabetic patients with nonalcoholic fatty liver disease
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Lippincott Williams and Wilkins
Abstract
Background Fibroscan is an effective and noninvasive tool to quantify fibrosis and steatosis in liver diseases including nonalcoholic fatty liver disease (NAFLD). Type-2-diabetes is a known risk factor for worse prognosis in NAFLD. In this study, we compare liver status in NAFDL diabetic and nondiabetic patients, identify potential risk factors, and determine the usefulness of Fibroscan in this population. Patients and methods The charts of all patients with NAFLD who underwent Fibroscan at our institution were reviewed. Fibroscan results, demographics, and clinical data were collected and analyzed using SPSS software. Results Of the 248 NAFLD patients, 73 (29.4%) were diabetic and 175 (70.6%) were nondiabetic. As detected by the NAFLD' liver stiffness measure, 35 (47.94%) diabetic patients had severe liver fibrosis (F4) in contrast to only 46 (26.3%) nondiabetics. Diabetic patients also presented more with hypertension, dyslipidemia, coronary artery disease, and chronic kidney disease. Liver steatosis, liver function tests, and noninvasive scores did not vary significantly between the two groups, except for γ-glutamyltransferase, prothrombin time-international normalized ratio, and BMI-alanine aminotransferase ratio-diabetes score. Diabetic patients had significantly lower high-density lipoproteins and low-density lipoproteins. Conclusion Fibroscan results and low-density lipoprotein are potential diagnostic factors of liver fibrosis in diabetic patients with NAFLD. Further studies are necessary to verify liver fibrosis diagnostic tools and prognostic and genetic markers in diabetic patients. © 2019 Lippincott Williams and Wilkins. All rights reserved.
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Fibroscan, Liver fibrosis, Nonalcoholic fatty liver disease, Type-2-diabetes, Adolescent, Adult, Aged, Aged, 80 and over, Biomarkers, Biopsy, Diabetes mellitus, type 2, Elasticity imaging techniques, Female, Follow-up studies, Humans, Lipoproteins, ldl, Liver, Liver cirrhosis, Male, Middle aged, Non-alcoholic fatty liver disease, Prospective studies, Risk factors, Severity of illness index, Young adult, Alanine aminotransferase, Gamma glutamyltransferase, High density lipoprotein, Low density lipoprotein, Biological marker, Alanine aminotransferase blood level, Article, Body mass, Chronic kidney failure, Controlled study, Coronary artery disease, Diabetes mellitus, Diabetic patient, Dyslipidemia, Fatty liver, Human, Hypertension, International normalized ratio, Liver function test, Liver stiffness, Major clinical study, Medical record review, Nonalcoholic fatty liver, Population research, Priority journal, Prothrombin time, Retrospective study, Risk factor, Blood, Complication, Diagnostic imaging, Elastography, Follow up, Non insulin dependent diabetes mellitus, Procedures, Prospective study, Very elderly