Recent advances in nanotherapeutics for multiple myeloma
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MDPI AG
Abstract
Anticancer therapies cannot be included in a one-size-fits-all scenario; it is imperative to adapt therapies to the tumor molecular profile and most importantly to develop target-specific therapeutics. Nanotherapeutics can combine molecular imaging with molecular therapy in order to provide the maximum benefit to patients in terms of disease prevention, identification, and treatment. Nanotechnology applied to therapy provides numerous advantages in diagnostics and in drug delivery, especially for those malignant cells that are diffcult to target or for drugs with poor bioavailability, such as those used for multiple myeloma (MM). This review summarizes the recent advances in the development of nanoparticle-based systems for the treatment of MM, taking into account the methods used for their functionalization, biocompatibility, and anticancer activity. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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Liposome, Multiple myeloma, Nanotechnology, Nanotherapeutics, Antineoplastic agent, Arsenic trioxide, Ascorbic acid, Bortezomib, Carbon nanotube, Carfilzomib, Chitosan, Daratumumab, Dexamethasone, Dna vaccine, Doxorubicin, Elotuzumab, Fullerene derivative, Gold nanoparticle, Graphene oxide, Ixazomib, Lenalidomide, Macrogol, Melphalan, Mesoporous silica nanoparticle, Nanomaterial, Nanoparticle, Paclitaxel, Panobinostat, Polycarbonate, Polyethyleneimine, Polyglactin, Polyvinyl alcohol, Pomalidomide, Porphyrin, Quantum dot, Single walled nanotube, Snake venom, Thalidomide, Titanium dioxide nanoparticle, Ultrasmall superparamagnetic iron oxide, Zinc oxide nanoparticle, Antineoplastic activity, Biocompatibility, Bone marrow suppression, Drug accumulation, Drug bioavailability, Drug blood level, Drug clearance, Drug cytotoxicity, Drug delivery system, Drug efficacy, Drug formulation, Drug half life, Drug potentiation, Drug selectivity, Drug targeting, Drug tolerability, Human, Ic50, Internalization, Micelle, Nanoencapsulation, Nanomedicine, Nonhuman, Particle size, Peripheral neuropathy, Photodynamic therapy, Photothermal therapy, Review, Sustained drug release, Vaccine immunogenicity