Sinusoidal obstruction syndrome/veno-occlusive disease: Current situation and perspectives - A position statement from the European Society for Blood and Marrow Transplantation (EBMT)
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Nature Publishing Group
Abstract
Sinusoidal obstruction syndrome or veno-occlusive disease (SOS/VOD) is a potentially life-threatening complication of hematopoietic SCT (HSCT). This review aims to highlight, on behalf of the European Society for Blood and Marrow Transplantation, the current knowledge on SOS/VOD pathophysiology, risk factors, diagnosis and treatments. Our perspectives on SOS/VOD are (i) to accurately identify its risk factors; (ii) to define new criteria for its diagnosis; (III) to search for SOS/VOD biomarkers and (iv) to propose prospective studies evaluating SOS/VOD prevention and treatment in adults and children. © 2015 Macmillan Publishers Limited.
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Adult, Biomarkers, Hematopoietic stem cell transplantation, Humans, Postoperative complications, Risk factors, Vascular diseases, Heparin, Low molecular weight heparin, Biological marker, Clinical effectiveness, Diagnostic test, Disease course, Disease marker, Europe, Human, Liver transplantation, Liver venoocclusive disease, Medical society, Pathophysiology, Practice guideline, Priority journal, Prospective study, Review, Risk assessment, Risk factor, Adverse effects, Blood