Ten-eleven translocation proteins and their role beyond DNA demethylation–what we can learn from the fly
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Bellwether Publishing, Ltd.
Abstract
Ten-eleven Translocation (TET) proteins have emerged as a family of epigenetic regulators that are important during development and have been implicated in various types of cancers. TET is a highly conserved protein that has orthologues in almost all multicellular organisms. Here, we review recent literature on the novel substrate specificity of this family of DNA 5-methylcytosine demethylases on DNA 6-methyladenine and RNA 5-methylcytosine that were first identified in the invertebrate model Drosophila. We focus on the biological role of these novel epigenetic marks in the fruit fly and mammals and highlight TET proteins’ critical function during development specifically in brain development. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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Cancer biology, Dna demethylation, Drosophila, Epigenetics, Neuroscience, Animals, Dna methylation, Drosophila proteins, Epigenesis, genetic, Gene expression regulation, developmental, Mixed function oxygenases, 5 methylcytosine, 5 methylcytosine demethylase, 6 n methyladenine, Carrier proteins and binding proteins, Cyclin dependent kinase inhibitor, Cyclin dependent kinase inhibitor 3, Dna (cytosine 5) methyltransferase 1, Dna methyltransferase, Dna methyltransferase 2, Green fluorescent protein, Messenger rna, Methyl cpg binding protein 2, Ras association domain family protein 2, Ten eleven translocation protein, Transcription factor, Ubiquitin like with phd and ring finger domain 2 protein, Unclassified drug, Yt521 b homology domain protein, Drosophila protein, Mixed function oxidase, Antigen binding, Bisulfite sequencing, Brain development, Cell differentiation, Crispr cas system, Depression, Dna modification, Dna repair, Dna replication, Dna structure, Drosophila melanogaster, Embryo development, Gene control, Gene expression, Gene mutation, Gene sequence, Genome imprinting, Glioblastoma, Hematopoiesis, Intron, Liquid chromatography, Liquid chromatography selective reaction monitoring, Mass spectrometry, Nanopore sequencing, Neuromuscular junction, Nonhuman, Nuclear reprogramming, Ovary, Phenotype, Pluripotent stem cell, Protein expression, Protein structure, Retroposon, Review, Rna methylation, Rna sequencing, Schizophrenia, Signal transduction, Systematic review, Ultra performance liquid chromatography, X chromosome, Animal, Chemistry, Gene expression regulation, Genetic epigenesis, Genetics, Growth, development and aging, Metabolism