Therapeutic applications and biological activities of bacterial bioactive extracts
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Springer Science and Business Media Deutschland GmbH
Abstract
Bacteria are rich in a wide variety of secondary metabolites, such as pigments, alkaloids, antibiotics, and others. These bioactive microbial products serve a great application in human and animal health. Their molecular diversity allows these natural products to possess several therapeutic attributes and biological functions. That’s why the current natural drug industry focuses on uncovering all the possible ailments and diseases that could be combated by bacterial extracts and their secondary metabolites. In this paper, we review the major utilizations of bacterial natural products for the treatment of cancer, inflammatory diseases, allergies, autoimmune diseases, infections and other diseases that threaten public health. We also elaborate on the identified biological activities of bacterial secondary metabolites including antibacterial, antifungal, antiviral and antioxidant activities all of which are essential nowadays with the emergence of drug-resistant microbial pathogens. Throughout this review, we discuss the possible mechanisms of actions in which bacterial-derived biologically active molecular entities could possess healing properties to inspire the development of new therapeutic agents in academia and industry. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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Anti-cancer, Antibacterial, Antifungal, Antioxidant, Antiviral, Bacterial extracts, Immunomodulation, Secondary metabolites, Animals, Anti-bacterial agents, Anti-infective agents, Antifungal agents, Bacteria, Biological products, Humans, Plant extracts, 3 benzylhexahydropyrrolo[1.2 a]pyrazine 1,4 dione, 4 aminobutyric acid, 4862f, 6 [4 deoxy 4 (2,4 tetradecadienoylglycylamino) glycero beta mannoheptopyranosylamino] 9h purine, Aclarubicin, Adr 159, Ahmpatinin ibu, Alkaloid derivative, Aminoglycoside derivative, Anthracycline derivative, Anthraquinone derivative, Antibiotic agent, Antifungal agent, Antiinfective agent, Antiinflammatory agent, Antimycin a1, Antineoplastic agent, Antineoplastic antibiotic, Antineoplastic antimetabolite, Asparaginase, Bacterial extract, Bacterial toxin, Bacterium lysate, Baicalein, Benzopyranone derivative, Benzoquinone derivative, Beta defensin, Biosurfactant, Bleomycin, Brartemicin, Butyric acid, C actinorhodin, Cadaverine, Carotenoid, Carzinophilin, Cholinesterase inhibitor, Cisplatin, Clecarmycin, Cremeomycin, Dactinomycin, Daptomycin, Daunorubicin, Depsipeptide, Dipeptide, Disaccharide, Diterpenoid, Doxorubicin, Ellagic acid, Enediyne, Epothilone, Exopolysaccharide, Flavonoid, Fluorouracil, Folic acid, Galvaquinone b, Gamma interferon, Geldanamycin, Gibberellin derivative, Glutathione, Glycolipid, Histone deacetylase inhibitor, Immunomodulating agent, Immunosuppressive agent, Interleukin 10, Interleukin 17, Interleukin 4, Interleukin 6, Iturin, Iturin a, Jadomycin, Jadomycin derivative, Juglomycin a, Kaempferol, Komodoquinone a, Kosinostatin, Kribelloside derivative, Lentztrehalose a, Lentztrehalose b, Lentztrehalose c, Lipopeptide, Mensacarcin, Metacycline, Mithramycin, Mitomycin, Mitomycin derivative, Mitoxantrone, Mohangamide a, Mohangamide b, Moromycin a, Moromycin b, N acetyldeformylantimycin, Natural product, Neoantimycin f, Nostoflan, Novobiocin, Om 85bv, Om 89, P1 37a, P1 37b, Paclitaxel, Pentostatin, Peptide derivative, Phenalamide a1, Phenolic acid derivative, Phenoxan, Pigment, Polysaccharide a, Probiotic agent, Prodigiosin, Propionic acid, Protein p8, Proteinase k activated parasporin 2aa 1 protein, Pyrrole derivative, Pyrrolo(1,2 a)pyrazine 1,4 dione hexahydro 3 (2 methylpropyl), Pyrrolo(1,2 a)pyrazine 1,4 dione hexahydro 3 (phenylmethyl), Quercetin 3 o beta rhamnopyranosyl (1-6) beta dextro glucopyranoside, Quercetin 3 o beta rhamnopyranosyl(1-6)beta dextro glucopyranoside, Quinone derivative, Ratjadon a, Romidepsin, Salinomycin, Saptomycin, Saquayamycin b, Serrawettin, Short chain fatty acid, Spicamycin, Steroid, Streptochlorin, Teralone derivative, Terpenoid derivative, Thiangazole, Thiocoraline, Trehalose, Trichostatin a, Tryptophan derivative, Unclassified drug, Uro vaxom, Urolithin a, Urukthapelstatin a, Valinomycin, Valinomycin derivative, Violacein, Xanthone derivative, Xiamycin d, Zinostatin, Biological product, Plant extract, Actinobacteria, Allergy, Antiangiogenic activity, Antibacterial activity, Antifungal activity, Antineoplastic activity, Antioxidant activity, Antiviral activity, Autoimmune disease, Biological activity, Breast cancer, Drug mechanism, Drug sensitization, Heart protection, Helicobacter pylori, Human, Infection, Inflammatory disease, Intestine flora, Malignant neoplasm, Metabolite, Metastasis inhibition, Neuroprotection, Nonhuman, Recurrent infection, Respiratory tract infection, Review, Rheumatoid arthritis, Streptomyces, Urinary tract infection, Animal, Bacterium