Therapeutic applications and biological activities of bacterial bioactive extracts

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dc.contributor.authorAbdelghani, Zainab
dc.contributor.authorHourani, Nancy
dc.contributor.authorZaidan, Zahraa
dc.contributor.authorDbaibo, Ghassan S.
dc.contributor.authorMrad, Marguerite
dc.contributor.authorHage-Sleiman, Rouba
dc.contributor.departmentBiochemistry and Molecular Genetics
dc.contributor.departmentPediatrics and Adolescent Medicine
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:38:10Z
dc.date.available2025-01-24T11:38:10Z
dc.date.issued2021
dc.description.abstractBacteria are rich in a wide variety of secondary metabolites, such as pigments, alkaloids, antibiotics, and others. These bioactive microbial products serve a great application in human and animal health. Their molecular diversity allows these natural products to possess several therapeutic attributes and biological functions. That’s why the current natural drug industry focuses on uncovering all the possible ailments and diseases that could be combated by bacterial extracts and their secondary metabolites. In this paper, we review the major utilizations of bacterial natural products for the treatment of cancer, inflammatory diseases, allergies, autoimmune diseases, infections and other diseases that threaten public health. We also elaborate on the identified biological activities of bacterial secondary metabolites including antibacterial, antifungal, antiviral and antioxidant activities all of which are essential nowadays with the emergence of drug-resistant microbial pathogens. Throughout this review, we discuss the possible mechanisms of actions in which bacterial-derived biologically active molecular entities could possess healing properties to inspire the development of new therapeutic agents in academia and industry. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
dc.identifier.doihttps://doi.org/10.1007/s00203-021-02505-1
dc.identifier.eid2-s2.0-85112081366
dc.identifier.pmid34370077
dc.identifier.urihttp://hdl.handle.net/10938/28999
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofArchives of Microbiology
dc.sourceScopus
dc.subjectAnti-cancer
dc.subjectAntibacterial
dc.subjectAntifungal
dc.subjectAntioxidant
dc.subjectAntiviral
dc.subjectBacterial extracts
dc.subjectImmunomodulation
dc.subjectSecondary metabolites
dc.subjectAnimals
dc.subjectAnti-bacterial agents
dc.subjectAnti-infective agents
dc.subjectAntifungal agents
dc.subjectBacteria
dc.subjectBiological products
dc.subjectHumans
dc.subjectPlant extracts
dc.subject3 benzylhexahydropyrrolo[1.2 a]pyrazine 1,4 dione
dc.subject4 aminobutyric acid
dc.subject4862f
dc.subject6 [4 deoxy 4 (2,4 tetradecadienoylglycylamino) glycero beta mannoheptopyranosylamino] 9h purine
dc.subjectAclarubicin
dc.subjectAdr 159
dc.subjectAhmpatinin ibu
dc.subjectAlkaloid derivative
dc.subjectAminoglycoside derivative
dc.subjectAnthracycline derivative
dc.subjectAnthraquinone derivative
dc.subjectAntibiotic agent
dc.subjectAntifungal agent
dc.subjectAntiinfective agent
dc.subjectAntiinflammatory agent
dc.subjectAntimycin a1
dc.subjectAntineoplastic agent
dc.subjectAntineoplastic antibiotic
dc.subjectAntineoplastic antimetabolite
dc.subjectAsparaginase
dc.subjectBacterial extract
dc.subjectBacterial toxin
dc.subjectBacterium lysate
dc.subjectBaicalein
dc.subjectBenzopyranone derivative
dc.subjectBenzoquinone derivative
dc.subjectBeta defensin
dc.subjectBiosurfactant
dc.subjectBleomycin
dc.subjectBrartemicin
dc.subjectButyric acid
dc.subjectC actinorhodin
dc.subjectCadaverine
dc.subjectCarotenoid
dc.subjectCarzinophilin
dc.subjectCholinesterase inhibitor
dc.subjectCisplatin
dc.subjectClecarmycin
dc.subjectCremeomycin
dc.subjectDactinomycin
dc.subjectDaptomycin
dc.subjectDaunorubicin
dc.subjectDepsipeptide
dc.subjectDipeptide
dc.subjectDisaccharide
dc.subjectDiterpenoid
dc.subjectDoxorubicin
dc.subjectEllagic acid
dc.subjectEnediyne
dc.subjectEpothilone
dc.subjectExopolysaccharide
dc.subjectFlavonoid
dc.subjectFluorouracil
dc.subjectFolic acid
dc.subjectGalvaquinone b
dc.subjectGamma interferon
dc.subjectGeldanamycin
dc.subjectGibberellin derivative
dc.subjectGlutathione
dc.subjectGlycolipid
dc.subjectHistone deacetylase inhibitor
dc.subjectImmunomodulating agent
dc.subjectImmunosuppressive agent
dc.subjectInterleukin 10
dc.subjectInterleukin 17
dc.subjectInterleukin 4
dc.subjectInterleukin 6
dc.subjectIturin
dc.subjectIturin a
dc.subjectJadomycin
dc.subjectJadomycin derivative
dc.subjectJuglomycin a
dc.subjectKaempferol
dc.subjectKomodoquinone a
dc.subjectKosinostatin
dc.subjectKribelloside derivative
dc.subjectLentztrehalose a
dc.subjectLentztrehalose b
dc.subjectLentztrehalose c
dc.subjectLipopeptide
dc.subjectMensacarcin
dc.subjectMetacycline
dc.subjectMithramycin
dc.subjectMitomycin
dc.subjectMitomycin derivative
dc.subjectMitoxantrone
dc.subjectMohangamide a
dc.subjectMohangamide b
dc.subjectMoromycin a
dc.subjectMoromycin b
dc.subjectN acetyldeformylantimycin
dc.subjectNatural product
dc.subjectNeoantimycin f
dc.subjectNostoflan
dc.subjectNovobiocin
dc.subjectOm 85bv
dc.subjectOm 89
dc.subjectP1 37a
dc.subjectP1 37b
dc.subjectPaclitaxel
dc.subjectPentostatin
dc.subjectPeptide derivative
dc.subjectPhenalamide a1
dc.subjectPhenolic acid derivative
dc.subjectPhenoxan
dc.subjectPigment
dc.subjectPolysaccharide a
dc.subjectProbiotic agent
dc.subjectProdigiosin
dc.subjectPropionic acid
dc.subjectProtein p8
dc.subjectProteinase k activated parasporin 2aa 1 protein
dc.subjectPyrrole derivative
dc.subjectPyrrolo(1,2 a)pyrazine 1,4 dione hexahydro 3 (2 methylpropyl)
dc.subjectPyrrolo(1,2 a)pyrazine 1,4 dione hexahydro 3 (phenylmethyl)
dc.subjectQuercetin 3 o beta rhamnopyranosyl (1-6) beta dextro glucopyranoside
dc.subjectQuercetin 3 o beta rhamnopyranosyl(1-6)beta dextro glucopyranoside
dc.subjectQuinone derivative
dc.subjectRatjadon a
dc.subjectRomidepsin
dc.subjectSalinomycin
dc.subjectSaptomycin
dc.subjectSaquayamycin b
dc.subjectSerrawettin
dc.subjectShort chain fatty acid
dc.subjectSpicamycin
dc.subjectSteroid
dc.subjectStreptochlorin
dc.subjectTeralone derivative
dc.subjectTerpenoid derivative
dc.subjectThiangazole
dc.subjectThiocoraline
dc.subjectTrehalose
dc.subjectTrichostatin a
dc.subjectTryptophan derivative
dc.subjectUnclassified drug
dc.subjectUro vaxom
dc.subjectUrolithin a
dc.subjectUrukthapelstatin a
dc.subjectValinomycin
dc.subjectValinomycin derivative
dc.subjectViolacein
dc.subjectXanthone derivative
dc.subjectXiamycin d
dc.subjectZinostatin
dc.subjectBiological product
dc.subjectPlant extract
dc.subjectActinobacteria
dc.subjectAllergy
dc.subjectAntiangiogenic activity
dc.subjectAntibacterial activity
dc.subjectAntifungal activity
dc.subjectAntineoplastic activity
dc.subjectAntioxidant activity
dc.subjectAntiviral activity
dc.subjectAutoimmune disease
dc.subjectBiological activity
dc.subjectBreast cancer
dc.subjectDrug mechanism
dc.subjectDrug sensitization
dc.subjectHeart protection
dc.subjectHelicobacter pylori
dc.subjectHuman
dc.subjectInfection
dc.subjectInflammatory disease
dc.subjectIntestine flora
dc.subjectMalignant neoplasm
dc.subjectMetabolite
dc.subjectMetastasis inhibition
dc.subjectNeuroprotection
dc.subjectNonhuman
dc.subjectRecurrent infection
dc.subjectRespiratory tract infection
dc.subjectReview
dc.subjectRheumatoid arthritis
dc.subjectStreptomyces
dc.subjectUrinary tract infection
dc.subjectAnimal
dc.subjectBacterium
dc.titleTherapeutic applications and biological activities of bacterial bioactive extracts
dc.typeReview

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