Epidermal growth factor receptor (EGFR) in the era of Precision Medicine: The tale of a perfect example of targeted therapy. A review

Simple item page
dc.contributor.authorHaddad, Joseph
dc.contributor.authorSlika, Silva
dc.contributor.authorMahfouz, Rami A.R.
dc.contributor.departmentPathology and Laboratory Medicine
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T12:09:55Z
dc.date.available2025-01-24T12:09:55Z
dc.date.issued2017
dc.description.abstractEpidermal growth factor receptor has been under the lights for the past few years as a perfect and typical example of a success story of targeted therapy. In the era of Precision Medicine, such modalities of treatment are highly implicated in the adequate choice of therapy for a wide variety of oncological diseases. This review article is about the different aspects of detection, application, and analysis of the epidermal growth factor receptor genetic mutations that constitute a key element in the initiation of targeted therapy. © 2016 Elsevier B.V.
dc.identifier.doihttps://doi.org/10.1016/j.mgene.2016.08.011
dc.identifier.eid2-s2.0-84994086647
dc.identifier.urihttp://hdl.handle.net/10938/32190
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofMeta Gene
dc.sourceScopus
dc.subjectEgfr
dc.subjectMedicine
dc.subjectPrecision
dc.subjectReview
dc.subjectAnaplastic lymphoma kinase
dc.subjectCeritinib
dc.subjectCetuximab
dc.subjectCrizotinib
dc.subjectDacomitinib
dc.subjectEpidermal growth factor receptor
dc.subjectErlotinib
dc.subjectGefitinib
dc.subjectK ras protein
dc.subjectPanitumumab
dc.subjectPlatelet derived growth factor
dc.subjectVasculotropin
dc.subjectCancer prognosis
dc.subjectClinical trial (topic)
dc.subjectColorectal carcinoma
dc.subjectDna sequence
dc.subjectGene mutation
dc.subjectGlioblastoma
dc.subjectHead and neck carcinoma
dc.subjectHigh performance liquid chromatography
dc.subjectHuman
dc.subjectImmunohistochemistry
dc.subjectLung cancer
dc.subjectMolecularly targeted therapy
dc.subjectNext generation sequencing
dc.subjectPersonalized medicine
dc.subjectPriority journal
dc.subjectProgression free survival
dc.subjectPyrosequencing
dc.subjectQuality of life
dc.subjectReverse transcription polymerase chain reaction
dc.subjectSensitivity and specificity
dc.subjectTreatment outcome
dc.subjectTreatment response
dc.titleEpidermal growth factor receptor (EGFR) in the era of Precision Medicine: The tale of a perfect example of targeted therapy. A review
dc.typeReview

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
2017-4696.pdf
Size:
296.81 KB
Format:
Adobe Portable Document Format
Download

Collections

Pathology and Laboratory Medicine