Role of MicroRNAs in Anesthesia-Induced Neurotoxicity in Animal Models and Neuronal Cultures: a Systematic Review
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Abstract
words (“microRNA” and “anesthesia”), to identify all published research studies on microRNAs and anesthesia. During the review process, data abstraction and methodological assessment was done by independent groups of reviewers. In total, 29 studies were recognized to be eligible and were thus involved in this systematic review. Anesthetic agents studied included sevoflurane, isoflurane, propofol, bupivacaine, and ketamine. More than 40 microRNAs were identified to have regulatory roles in anesthesia-induced neurotoxicity. This field of study still comprises several gaps that should be filled by conducting basic, clinical, and translational research in the future to decipher the exact role of microRNAs and their functions in the context of anesthesia-induced neurotoxicity. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
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Anesthesia, Microrna, Neurotoxicity, Systematic review, Anesthetics, Animals, Brain, Cells, cultured, Gene expression regulation, Humans, Micrornas, Neurogenesis, Neurons, Bupivacaine, Isoflurane, Ketamine, Microrna 107, Microrna 129 3p, Microrna 132, Microrna 136, Microrna 145, Microrna 15a, Microrna 183, Microrna 183 3p, Microrna 19a, Microrna 20a, Microrna 20b, Microrna 29a, Microrna 300, Microrna 33 5p, Microrna 34a, Microrna 361, Microrna 375, Microrna 382, Microrna 383, Microrna 532, Microrna 96, Microrna 99a, Propofol, Sevoflurane, Unclassified drug, Anesthetic agent, Cognitive defect, Gene expression profiling, Gene function, Human, Human embryonic stem cell, Memory disorder, Microarray analysis, Mrna expression level, Nerve cell culture, Neuroprotection, Nonhuman, Priority journal, Real time polymerase chain reaction, Review, Adverse event, Animal, Cell culture, Drug effect, Metabolism, Nerve cell, Nervous system development