Role of MicroRNAs in Anesthesia-Induced Neurotoxicity in Animal Models and Neuronal Cultures: a Systematic Review

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dc.contributor.authorBahmad, Hisham F.
dc.contributor.authorDarwish, Batoul
dc.contributor.authorDargham, Karem Bou
dc.contributor.authorMachmouchi, Rabih
dc.contributor.authorDargham, Bahaa Bou
dc.contributor.authorOsman, Maarouf
dc.contributor.authorKhechen, Zonaida Al
dc.contributor.authorEl Housheimi, Nour
dc.contributor.authorAbou-Kheir, Wassim G.
dc.contributor.authorChamaa, Farah
dc.contributor.departmentAnatomy, Cell Biology, and Physiological Sciences
dc.contributor.departmentAnesthesiology
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:36:53Z
dc.date.available2025-01-24T11:36:53Z
dc.date.issued2020
dc.description.abstractwords (“microRNA” and “anesthesia”), to identify all published research studies on microRNAs and anesthesia. During the review process, data abstraction and methodological assessment was done by independent groups of reviewers. In total, 29 studies were recognized to be eligible and were thus involved in this systematic review. Anesthetic agents studied included sevoflurane, isoflurane, propofol, bupivacaine, and ketamine. More than 40 microRNAs were identified to have regulatory roles in anesthesia-induced neurotoxicity. This field of study still comprises several gaps that should be filled by conducting basic, clinical, and translational research in the future to decipher the exact role of microRNAs and their functions in the context of anesthesia-induced neurotoxicity. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
dc.identifier.doihttps://doi.org/10.1007/s12640-019-00135-6
dc.identifier.eid2-s2.0-85074859027
dc.identifier.pmid31707631
dc.identifier.urihttp://hdl.handle.net/10938/28748
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofNeurotoxicity Research
dc.sourceScopus
dc.subjectAnesthesia
dc.subjectMicrorna
dc.subjectNeurotoxicity
dc.subjectSystematic review
dc.subjectAnesthetics
dc.subjectAnimals
dc.subjectBrain
dc.subjectCells, cultured
dc.subjectGene expression regulation
dc.subjectHumans
dc.subjectMicrornas
dc.subjectNeurogenesis
dc.subjectNeurons
dc.subjectBupivacaine
dc.subjectIsoflurane
dc.subjectKetamine
dc.subjectMicrorna 107
dc.subjectMicrorna 129 3p
dc.subjectMicrorna 132
dc.subjectMicrorna 136
dc.subjectMicrorna 145
dc.subjectMicrorna 15a
dc.subjectMicrorna 183
dc.subjectMicrorna 183 3p
dc.subjectMicrorna 19a
dc.subjectMicrorna 20a
dc.subjectMicrorna 20b
dc.subjectMicrorna 29a
dc.subjectMicrorna 300
dc.subjectMicrorna 33 5p
dc.subjectMicrorna 34a
dc.subjectMicrorna 361
dc.subjectMicrorna 375
dc.subjectMicrorna 382
dc.subjectMicrorna 383
dc.subjectMicrorna 532
dc.subjectMicrorna 96
dc.subjectMicrorna 99a
dc.subjectPropofol
dc.subjectSevoflurane
dc.subjectUnclassified drug
dc.subjectAnesthetic agent
dc.subjectCognitive defect
dc.subjectGene expression profiling
dc.subjectGene function
dc.subjectHuman
dc.subjectHuman embryonic stem cell
dc.subjectMemory disorder
dc.subjectMicroarray analysis
dc.subjectMrna expression level
dc.subjectNerve cell culture
dc.subjectNeuroprotection
dc.subjectNonhuman
dc.subjectPriority journal
dc.subjectReal time polymerase chain reaction
dc.subjectReview
dc.subjectAdverse event
dc.subjectAnimal
dc.subjectCell culture
dc.subjectDrug effect
dc.subjectMetabolism
dc.subjectNerve cell
dc.subjectNervous system development
dc.titleRole of MicroRNAs in Anesthesia-Induced Neurotoxicity in Animal Models and Neuronal Cultures: a Systematic Review
dc.typeReview

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