Immunopathological features of air pollution and its impact on inflammatory airway diseases (IAD)
Loading...
Date
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Inc.
Abstract
Air pollution causes significant morbidity and mortality in patients with inflammatory airway diseases (IAD) such as allergic rhinitis (AR), chronic rhinosinusitis (CRS), asthma, and chronic obstructive pulmonary disease (COPD). Oxidative stress in patients with IAD can induce eosinophilic inflammation in the airways, augment atopic allergic sensitization, and increase susceptibility to infection. We reviewed emerging data depicting the involvement of oxidative stress in IAD patients. We evaluated biomarkers, outcome measures and immunopathological alterations across the airway mucosal barrier following exposure, particularly when accentuated by an infectious insult. © 2020 The Authors
Description
Keywords
Air pollution, Antioxidant, Inflammatory airway disease, Oxidative stress biomarkers, Tobacco smoke, Allergen, Biological marker, Formaldehyde, Nanoparticle, Nitrogen oxide, Ozone, Reactive oxygen metabolite, Volatile organic compound, Adaptive immunity, Airway epithelium cell, Allergic asthma, Allergic rhinitis, Atopy, Chronic obstructive lung disease, Chronic rhinosinusitis, Dust, Environmental exposure, Exhaust gas, Human, Immunopathology, Infection sensitivity, Infectious agent, Innate immunity, Nonhuman, Outcome assessment, Oxidative stress, Particulate matter, Priority journal, Respiratory mucosa, Respiratory tract allergy, Respiratory tract infection, Respiratory tract inflammation, Review