Granulocytic sarcoma following acute myelogenous leukemia type fab-M5 associated with t(6;12) involving a rearrangement of the etv6 locus

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dc.contributor.authorEl-Rayess, Hebah M.
dc.contributor.authorRefaat, Marwan M.
dc.contributor.authorSaab, Karim R.
dc.contributor.authorEl Jamal, Nadim
dc.contributor.authorDey, Bimalangshu R.
dc.contributor.departmentInternal Medicine
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:49:52Z
dc.date.available2025-01-24T11:49:52Z
dc.date.issued2017
dc.description.abstractBackground: Acute myelogenous leukemia is a cancer that affects myeloid cells. Several complications occur due to acute myelogenous leukemia of which is granulocytic sarcoma. This case report discusses the analysis of skin abnormalities in an acute myelogenous leukemia patient. Case description: Skin examination and fine needle aspiration of the nodules in comparison with previous bone marrow biopsy confirmed the diagnosis of myeloid sarcoma. Cytogenetic analysis showed t(6;12) involving a rearrangement of the ETV6 locus. Conclusions: This is a unique report of a case of granulocytic sarcoma following acute myelogenous leukemia type 5 with t(6;12) involving a rearrangement of the ETV6 locus. Several precautions should be made in diagnosing such conditions. A combination of systemic chemotherapy and local electron-beam therapy or PUVA to treat chemotherapy resistant leukemia cutis lesions is needed.
dc.identifier.doihttps://doi.org/10.12816/0035673
dc.identifier.eid2-s2.0-85017354591
dc.identifier.urihttp://hdl.handle.net/10938/30915
dc.language.isoen
dc.publisherLebanese Order of Physicians
dc.relation.ispartofJournal Medical Libanais
dc.sourceScopus
dc.subjectAcute myelogenous leukemia
dc.subjectGranulocytic sarcoma
dc.subjectLeukemia cutis
dc.subjectRearrangement
dc.subjectCytarabine
dc.subjectDaunorubicin
dc.subjectAbdominal hysterectomy
dc.subjectAcute myeloid leukemia
dc.subjectAdult
dc.subjectAllogeneic hematopoietic stem cell transplantation
dc.subjectArticle
dc.subjectCase report
dc.subjectChromosome analysis
dc.subjectDisease association
dc.subjectDysmenorrhea
dc.subjectEnterococcal infection
dc.subjectFatigue
dc.subjectFemale
dc.subjectFine needle aspiration biopsy
dc.subjectFluorescence in situ hybridization
dc.subjectGene locus
dc.subjectGene rearrangement
dc.subjectHuman
dc.subjectIron deficiency anemia
dc.subjectMiddle aged
dc.subjectMucosa inflammation
dc.subjectPneumonia
dc.subjectRemission
dc.subjectRespiratory tract disease
dc.subjectSkin bruising
dc.subjectSkin discoloration
dc.subjectSkin examination
dc.subjectSkin nodule
dc.subjectUterus myoma
dc.titleGranulocytic sarcoma following acute myelogenous leukemia type fab-M5 associated with t(6;12) involving a rearrangement of the etv6 locus
dc.typeArticle

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