Progressive multifocal leukoencephalopathy in patients receiving rituximab and cyclophosphamide after haplo-identical T-cell replete transplantation and review of the literature
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Elsevier Masson SAS
Abstract
John Cunningham virus (JCV) reactivation, occurring mainly in immunocompromised patients, leads to progressive multifocal leukoencephalopathy, an uncommon but lethal disease. JCV reactivation after T-cell replete haploidentical stem cell transplantation, in the pre-cyclophosphamide era, is poorly represented in the literature. We therefore describe two cases of acute myeloid leukemia who developed JCV reactivation after receiving cyclophosphamide and rituximab post haploidentical stem cell transplantation, and review the literature, aiming to a better understanding of the disease course and its risk factors. © 2017
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Haploidentical stem cell transplantation, John cunningham virus, Progressive multifocal leukoencephalopathy, Rituximab, Cyclophosphamide, Female, Hematopoietic stem cell transplantation, Humans, Immunocompromised host, Immunosuppressive agents, Jc virus, Leukemia, myeloid, acute, Leukoencephalopathy, progressive multifocal, Middle aged, Transplantation conditioning, Transplantation, haploidentical, Virus activation, Azacitidine, Busulfan, Colistin, Cyclosporine, Cytarabine, Fludarabine, Idarubicin, Levofloxacin, Meropenem, Mycophenolate mofetil, Oseltamivir, Piperacillin plus tazobactam, Sorafenib, Thiotepa, Thymocyte antibody, Tigecycline, Valganciclovir, Immunosuppressive agent, Acute myeloid leukemia, Adult, Bacteremia, Bacterial infection, Blood toxicity, Bone marrow biopsy, Bronchoalveolar lavage fluid, Cancer chemotherapy, Case report, Clinical article, Clinical feature, Continuous infusion, Cytomegalovirus, Cytomegalovirus infection, Drug effect, Drug withdrawal, Flow cytometry, Graft versus host reaction, Haploidentical transplantation, Human, Human herpesvirus 6, Human tissue, Immunosuppressive treatment, Influenza, Maintenance therapy, Mitral valve regurgitation, Multiple cycle treatment, Nonhuman, Polymerase chain reaction, Quantitative analysis, Review, Stem cell transplantation, Transesophageal echocardiography, Treatment duration, Virus reactivation, Immunocompromised patient, Immunology, Physiology, Procedures