Progressive multifocal leukoencephalopathy in patients receiving rituximab and cyclophosphamide after haplo-identical T-cell replete transplantation and review of the literature

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dc.contributor.authorSalem, Rana J.
dc.contributor.authorMassoud, Radwan
dc.contributor.authorKanj, Souha S.
dc.contributor.authorHamdan, M.
dc.contributor.authorSalman, Rida
dc.contributor.authorBazarbachi, Ali Abdul Hamid
dc.contributor.authorEl-Cheikh, Jean
dc.contributor.departmentSpecialized Clinical Programs and Services
dc.contributor.departmentInternal Medicine
dc.contributor.departmentDiagnostic Radiology
dc.contributor.departmentBone Marrow Transplantation (BMT) Program
dc.contributor.departmentInfectious Diseases Services and Programs
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T12:20:22Z
dc.date.available2025-01-24T12:20:22Z
dc.date.issued2017
dc.description.abstractJohn Cunningham virus (JCV) reactivation, occurring mainly in immunocompromised patients, leads to progressive multifocal leukoencephalopathy, an uncommon but lethal disease. JCV reactivation after T-cell replete haploidentical stem cell transplantation, in the pre-cyclophosphamide era, is poorly represented in the literature. We therefore describe two cases of acute myeloid leukemia who developed JCV reactivation after receiving cyclophosphamide and rituximab post haploidentical stem cell transplantation, and review the literature, aiming to a better understanding of the disease course and its risk factors. © 2017
dc.identifier.doihttps://doi.org/10.1016/j.retram.2017.10.002
dc.identifier.eid2-s2.0-85033592521
dc.identifier.pmid29132903
dc.identifier.urihttp://hdl.handle.net/10938/34266
dc.language.isoen
dc.publisherElsevier Masson SAS
dc.relation.ispartofCurrent Research in Translational Medicine
dc.sourceScopus
dc.subjectHaploidentical stem cell transplantation
dc.subjectJohn cunningham virus
dc.subjectProgressive multifocal leukoencephalopathy
dc.subjectRituximab
dc.subjectCyclophosphamide
dc.subjectFemale
dc.subjectHematopoietic stem cell transplantation
dc.subjectHumans
dc.subjectImmunocompromised host
dc.subjectImmunosuppressive agents
dc.subjectJc virus
dc.subjectLeukemia, myeloid, acute
dc.subjectLeukoencephalopathy, progressive multifocal
dc.subjectMiddle aged
dc.subjectTransplantation conditioning
dc.subjectTransplantation, haploidentical
dc.subjectVirus activation
dc.subjectAzacitidine
dc.subjectBusulfan
dc.subjectColistin
dc.subjectCyclosporine
dc.subjectCytarabine
dc.subjectFludarabine
dc.subjectIdarubicin
dc.subjectLevofloxacin
dc.subjectMeropenem
dc.subjectMycophenolate mofetil
dc.subjectOseltamivir
dc.subjectPiperacillin plus tazobactam
dc.subjectSorafenib
dc.subjectThiotepa
dc.subjectThymocyte antibody
dc.subjectTigecycline
dc.subjectValganciclovir
dc.subjectImmunosuppressive agent
dc.subjectAcute myeloid leukemia
dc.subjectAdult
dc.subjectBacteremia
dc.subjectBacterial infection
dc.subjectBlood toxicity
dc.subjectBone marrow biopsy
dc.subjectBronchoalveolar lavage fluid
dc.subjectCancer chemotherapy
dc.subjectCase report
dc.subjectClinical article
dc.subjectClinical feature
dc.subjectContinuous infusion
dc.subjectCytomegalovirus
dc.subjectCytomegalovirus infection
dc.subjectDrug effect
dc.subjectDrug withdrawal
dc.subjectFlow cytometry
dc.subjectGraft versus host reaction
dc.subjectHaploidentical transplantation
dc.subjectHuman
dc.subjectHuman herpesvirus 6
dc.subjectHuman tissue
dc.subjectImmunosuppressive treatment
dc.subjectInfluenza
dc.subjectMaintenance therapy
dc.subjectMitral valve regurgitation
dc.subjectMultiple cycle treatment
dc.subjectNonhuman
dc.subjectPolymerase chain reaction
dc.subjectQuantitative analysis
dc.subjectReview
dc.subjectStem cell transplantation
dc.subjectTransesophageal echocardiography
dc.subjectTreatment duration
dc.subjectVirus reactivation
dc.subjectImmunocompromised patient
dc.subjectImmunology
dc.subjectPhysiology
dc.subjectProcedures
dc.titleProgressive multifocal leukoencephalopathy in patients receiving rituximab and cyclophosphamide after haplo-identical T-cell replete transplantation and review of the literature
dc.typeReview

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