Role of the Nox4/AMPK/mTOR signaling axe in adipose inflammation-induced kidney injury
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Portland Press Ltd
Abstract
Diabetic kidney disease is one of the most serious complications of diabetes worldwide and is the leading cause of end-stage renal disease. While research has primarily focused on hyperglycemia as a key player in the pathophysiology of diabetic complications, recently, increasing evidence have underlined the role of adipose infammation in modulating the development and/or progression of diabetic kidney disease. This review focuses on how adipose infammation contribute to diabetic kidney disease. Furthermore, it discusses in detail the underlying mechanisms of adipose infammation, including pro-infammatory cytokines, oxidative stress, and AMPK/mTOR signaling pathway and critically describes their role in diabetic kidney disease. This in-depth understanding of adipose infammation and its impact on diabetic kidney disease highlights the need for novel interventions in the treatment of diabetic complications. © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
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Adipose tissue, Amp-activated protein kinases, Animals, Humans, Inflammation, Kidney, Nadph oxidase 4, Signal transduction, Tor serine-threonine kinases, Alpha tocopherol, Ascorbic acid, Beta carotene, Catalase, Glutathione, Glutathione peroxidase, Hydroxymethylglutaryl coenzyme a reductase kinase, Intercellular adhesion molecule 1, Interleukin 10, Interleukin 1beta, Interleukin 6, Interleukin 8, Low density lipoprotein cholesterol, Macrophage migration inhibition factor, Mammalian target of rapamycin, Metformin, Monocyte chemotactic protein 1, Nerve growth factor, Rapamycin, Reduced nicotinamide adenine dinucleotide phosphate oxidase 4, Retinol, Somatomedin, Sterol regulatory element binding protein 1, Superoxide dismutase, Toll like receptor 4, Transforming growth factor beta, Triacylglycerol, Tumor necrosis factor, Vasculotropin, Target of rapamycin kinase, Adipocyte, Ampk signaling, Antioxidant activity, Cardiovascular disease, Cross linking, Cytokine production, Diabetic nephropathy, End stage renal disease, Human, Hyperlipidemia, Hypoxia, Insulin resistance, Intra-abdominal fat, Kidney injury, Lipotoxicity, Lymphocytic infiltration, Mediator release, Mtor signaling, Non insulin dependent diabetes mellitus, Nonhuman, Obesity, Oxidative stress, Pathogenesis, Priority journal, Review, Animal, Injury, Metabolism, Pathology