Noxa: Role in cancer pathogenesis and treatment
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Bentham Science Publishers B.V.
Abstract
The B-cell lymphoma 2 (Bcl-2) family proteins play an important role in regulating apoptosis, or programmed cell death, in response to several extracellular and intracellular signals. These proteins are either pro-apoptotic or anti-apoptotic. The pro-apoptotic Noxa is a Bcl-2 family protein that belongs to a subclass of BH3-only proteins. Noxa induces apoptosis via p53-dependent and/or p53-independent mechanisms. While Noxa may play a limited role in apoptosis, it is a crucial player that interacts with several proteins in the apoptosis pathway, highlighting its importance in the pathogenesis and treatment of certain cancers. In this review, we will elucidate the mechanisms by which Noxa regulates apoptosis and review the roles of chemotherapeutic drugs in relation to Noxa. © 2018 Bentham Science Publishers.
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Apoptosis, B-cell lymphoma 2, Bcl-2, Cancer, Noxa, P53, Antineoplastic agents, Bcl-associated death protein, Humans, Mitochondria, Myeloid cell leukemia sequence 1 protein, Neoplasms, Proto-oncogene proteins c-bcl-2, Signal transduction, Tumor suppressor protein p53, Up-regulation, 4 [4 (4' chloro 2 biphenylylmethyl) 1 piperazinyl] n [4 [3 dimethylamino 1 (phenylthiomethyl)propylamino] 3 nitrobenzenesulfonyl]benzamide, Activating transcription factor 3, Activating transcription factor 4, Bcl2 related protein a1, Bh3 protein, Bim protein, Cisplatin, Gossypol, Growth differentiation factor 15, Histone deacetylase inhibitor, Hypoxia inducible factor 1alpha, Isosorbide, Navitoclax, Nedd8 protein, Obatoclax, Protein bad, Protein bak, Protein bax, Protein bcl 2, Protein bcl w, Protein bcl xl, Protein kinase c, Protein mcl 1, Protein noxa, Protein p53, Puma protein, Transcription factor e2f1, Tumor protein p73, Unindexed drug, Venetoclax, Antineoplastic agent, Bad protein, human, Mcl1 protein, human, Pmaip1 protein, human, Acute lymphoblastic leukemia, Acute myeloid leukemia, Cancer chemotherapy, Cancer therapy, Chromatin, Chronic lymphatic leukemia, Colorectal cancer, Cytogenetics, Down regulation, Ectopic expression, Histology, Human, Immunomodulation, Melanoma, Multiple myeloma, Non small cell lung cancer, Ovary cancer, Pathogenesis, Phase 2 clinical trial (topic), Prostate cancer, Protein expression, Protein processing, Protein splicing, Review, Rhabdomyosarcoma, Small cell lung cancer, Static electricity, Ubiquitination, Upregulation, Metabolism, Mitochondrion, Neoplasm