Thalassemia and malignancies: Updates from the literature

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dc.contributor.authorHodroj, Mohammad Hassan
dc.contributor.authorTaher, Ali T.
dc.contributor.departmentInternal Medicine
dc.contributor.departmentDivision of Hematology Oncology
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:45:35Z
dc.date.available2025-01-24T11:45:35Z
dc.date.issued2023
dc.description.abstractThalassemia management has undergone significant development with the advancement in iron chelation therapy, which has led to a prolonged life expectancy. This has been accompanied by the emergence of several new morbidities and chronic diseases, including cancer. Over the years, multiple cases of solid and hematologic malignancies in thalassemia patients have been reported in the literature, with no clear mechanism for the development of cancer in these patients despite a number of potential mechanisms. However, the results of many studies have been contradictory regarding the risk of development of malignancies in thalassemia. The present review aims to discuss the available data on cancer and thalassemia in the literature, with the latest updates regarding possible malignancy development mechanisms, risks, and the most commonly reported types. © 2023 The New York Academy of Sciences.
dc.identifier.doihttps://doi.org/10.1111/nyas.15061
dc.identifier.eid2-s2.0-85177184196
dc.identifier.pmid37676814
dc.identifier.urihttp://hdl.handle.net/10938/30580
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofAnnals of the New York Academy of Sciences
dc.sourceScopus
dc.subjectMalignancies
dc.subjectNon-transfusion-dependent thalassemia
dc.subjectThalassemia
dc.subjectTransfusion-dependent thalassemia
dc.subjectBlood transfusion
dc.subjectHematologic neoplasms
dc.subjectHumans
dc.subjectIron chelating agents
dc.subjectIron overload
dc.subjectNeoplasms
dc.subjectIron chelating agent
dc.subjectCancer prevention
dc.subjectCytomegalovirus
dc.subjectDeveloping country
dc.subjectDisease predisposition
dc.subjectHematologic malignancy
dc.subjectHepatitis c virus
dc.subjectIron chelation
dc.subjectPathophysiology
dc.subjectReview
dc.subjectTumor virus
dc.subjectComplication
dc.subjectHematologic disease
dc.subjectHuman
dc.subjectNeoplasm
dc.subjectProcedures
dc.titleThalassemia and malignancies: Updates from the literature
dc.typeReview

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