A transgenic Drosophila melanogaster model to study human T-lymphotropic virus oncoprotein Tax-1-driven transformation in vivo

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dc.contributor.authorShirinian, Margret
dc.contributor.authorKambris, Zakaria
dc.contributor.authorHamadeh, Lama N.
dc.contributor.authorGrabbe, Caroline
dc.contributor.authorJourno, Chloé
dc.contributor.authorMahieux, Renaud
dc.contributor.authorBazarbachi, Ali Abdul Hamid
dc.contributor.departmentExperimental Pathology, Microbiology, and Immunology
dc.contributor.departmentDepartment of Biology
dc.contributor.departmentInternal Medicine
dc.contributor.departmentAnatomy, Cell Biology, and Physiological Sciences
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.facultyFaculty of Arts and Sciences (FAS)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:38:54Z
dc.date.available2025-01-24T11:38:54Z
dc.date.issued2015
dc.description.abstractHuman T-cell lymphotropic virus type 1 (HTLV-1)-induced adult T-cell leukemia/lymphoma is an aggressive malignancy. HTLV-2 is genetically related to HTLV-1 but does not cause any malignant disease. HTLV-1 Tax transactivator (Tax-1) contributes to leukemogenesis via NF-κB. We describe transgenic Drosophila models expressing Tax in the compound eye and plasmatocytes. We demonstrate that Tax-1 but not Tax-2 induces ommatidial perturbation and increased plasmatocyte proliferation and that the eye phenotype is dependent on Kenny (IKKγ/NEMO), thus validating this new in vivo model. © 2015, American Society for Microbiology.
dc.identifier.doihttps://doi.org/10.1128/JVI.00918-15
dc.identifier.eid2-s2.0-84937705501
dc.identifier.pmid25995252
dc.identifier.urihttp://hdl.handle.net/10938/29096
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.relation.ispartofJournal of Virology
dc.sourceScopus
dc.subjectAnimals
dc.subjectCell transformation, viral
dc.subjectDisease models, animal
dc.subjectDrosophila melanogaster
dc.subjectEye
dc.subjectGene products, tax
dc.subjectHtlv-i infections
dc.subjectHuman t-lymphotropic virus 1
dc.subjectHuman t-lymphotropic virus 2
dc.subjectHumans
dc.subjectI kappa b kinase gamma
dc.subjectOncoprotein
dc.subjectProtein tax 1
dc.subjectProtein tax 2
dc.subjectTransactivator protein
dc.subjectUnclassified drug
dc.subjectTax protein
dc.subjectTax protein, human t-lymphotrophic virus 1
dc.subjectTax protein, human t-lymphotrophic virus 2
dc.subjectAnimal cell
dc.subjectAnimal experiment
dc.subjectAnimal model
dc.subjectAnimal tissue
dc.subjectArticle
dc.subjectCell proliferation
dc.subjectCell transformation
dc.subjectControlled study
dc.subjectDisease model
dc.subjectDisease severity
dc.subjectEye development
dc.subjectEye disease
dc.subjectGal4 gene
dc.subjectGene
dc.subjectGene dosage
dc.subjectGene expression regulation
dc.subjectGene function
dc.subjectGene identification
dc.subjectGene interaction
dc.subjectGene overexpression
dc.subjectGmr gene
dc.subjectIn vivo study
dc.subjectLymphocyte transformation
dc.subjectMolecular cloning
dc.subjectNonhuman
dc.subjectOncogene
dc.subjectPhenotype
dc.subjectPlasma cell
dc.subjectPriority journal
dc.subjectPromoter region
dc.subjectProtein function
dc.subjectProtein protein interaction
dc.subjectRna interference
dc.subjectRough eye disease
dc.subjectScanning electron microscopy
dc.subjectTax 1 gene
dc.subjectTranscription regulation
dc.subjectTransgenic drosophila
dc.subjectAnimal
dc.subjectGenetics
dc.subjectHuman
dc.subjectHuman t cell leukemia virus infection
dc.subjectMetabolism
dc.subjectPathology
dc.subjectPhysiology
dc.subjectVirology
dc.subjectVirus cell transformation
dc.titleA transgenic Drosophila melanogaster model to study human T-lymphotropic virus oncoprotein Tax-1-driven transformation in vivo
dc.typeArticle

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