Catastrophic relapses following initiation of dimethyl fumarate in two patients with neuromyelitis optica spectrum disorder

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dc.contributor.authorYamout, Bassem I.
dc.contributor.authorBeaini, Shawkat
dc.contributor.authorZeineddine, Maya M.
dc.contributor.authorAkkawi, Nabil Maalikjy
dc.contributor.departmentNeurology
dc.contributor.departmentNehme and Therese Tohme Multiple Sclerosis (MS) Center
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T12:07:31Z
dc.date.available2025-01-24T12:07:31Z
dc.date.issued2017
dc.description.abstractWe report two cases of neuromyelitis optica spectrum disorder (NMOSD) who were misdiagnosed as multiple sclerosis (MS) and developed catastrophic relapses following initiation of dimethyl fumarate. Both patients developed a severe myelitis extending from the cervical cord to the medulla with significant cord swelling, resulting in complete quadriplegia and respiratory difficulties, in addition to severe bilateral visual loss in one patient. It is of note that both catastrophic relapses occurred 2 and 3 months following initiation of dimethyl fumarate. © 2017, © The Author(s), 2017.
dc.identifier.doihttps://doi.org/10.1177/1352458517694086
dc.identifier.eid2-s2.0-85046117279
dc.identifier.pmid28391740
dc.identifier.urihttp://hdl.handle.net/10938/31545
dc.language.isoen
dc.publisherSAGE Publications Ltd
dc.relation.ispartofMultiple Sclerosis
dc.sourceScopus
dc.subjectAquaporin 4
dc.subjectDimethyl fumarate
dc.subjectNeuromyelitis optica
dc.subjectAdult
dc.subjectBlindness
dc.subjectDiagnostic errors
dc.subjectFatal outcome
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunosuppressive agents
dc.subjectMiddle aged
dc.subjectMultiple sclerosis
dc.subjectMyelitis
dc.subjectQuadriplegia
dc.subjectRecurrence
dc.subjectAzathioprine
dc.subjectBeta interferon
dc.subjectCorticotropin
dc.subjectFumaric acid dimethyl ester
dc.subjectLymphocyte antibody
dc.subjectLymphocyte antigen
dc.subjectMethylprednisolone
dc.subjectPrednisone
dc.subjectImmunosuppressive agent
dc.subjectAquaporin 4 antibody
dc.subjectBeta1a interferon
dc.subjectArticle
dc.subjectBlurred vision
dc.subjectBrain stem injury
dc.subjectCase report
dc.subjectCerebrospinal fluid examination
dc.subjectCervical myelopathy
dc.subjectCervical spinal cord
dc.subjectCervical spinal cord injury
dc.subjectDiagnostic error
dc.subjectDisease exacerbation
dc.subjectDisease severity
dc.subjectDrug megadose
dc.subjectDrug substitution
dc.subjectDrug withdrawal
dc.subjectDysesthesia
dc.subjectHuman
dc.subjectImmunofluorescence test
dc.subjectLumbar puncture
dc.subjectLymphocyte count
dc.subjectMedulla oblongata
dc.subjectMuscle weakness
dc.subjectMyelooptic neuropathy
dc.subjectNeuroimaging
dc.subjectNuclear magnetic resonance imaging
dc.subjectOptic chiasm
dc.subjectOptic nerve disease
dc.subjectPlasmapheresis
dc.subjectRelapse
dc.subjectRespiratory failure
dc.subjectSpinal cord disease
dc.subjectTerminal disease
dc.subjectVertigo
dc.subjectVisual evoked potential
dc.subjectVisual impairment
dc.subjectWhite matter lesion
dc.subjectChemically induced
dc.subjectFatality
dc.subjectRecurrent disease
dc.subjectAntibody blood level
dc.subjectBrain edema
dc.subjectClinical article
dc.subjectCord swelling
dc.subjectIndirect immunofluorescence assay
dc.subjectLebanese
dc.subjectLimb weakness
dc.subjectRespiratory arrest
dc.subjectRespiratory distress
dc.subjectSwelling
dc.subjectSyrian
dc.subjectTreatment refusal
dc.titleCatastrophic relapses following initiation of dimethyl fumarate in two patients with neuromyelitis optica spectrum disorder
dc.typeArticle

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