Imiquimod in dermatology: an overview
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Blackwell Publishing Ltd
Abstract
Imiquimod is an immune response modifier commercially available as a 3.75 and 5% cream. Topical imiquimod stimulates the innate and adaptive immune responses and induces cytokine production. This allows its use for the treatment of a wide variety of benign and malignant skin conditions due to its potential antiviral, antitumor, and immunoregulatory effects. Currently, topical imiquimod is US Food and Drug Administration (FDA)-approved for the treatment of anogenital warts, actinic keratosis, and superficial basal cell carcinomas. However, it has also shown a beneficial effect in the treatment of many other skin disorders. In this review, we describe existing evidence on the mechanism of action of topical imiquimod, its FDA-approved indications, off-label uses, and side effects. © 2016 The International Society of Dermatology
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Imiquimod, Actinic keratosis, Angioneurotic edema, Application site scabbing, Arthralgia, Basal cell carcinoma, Capillary hemangioma, Cellulitis, Condyloma acuminatum, Conjunctivitis, Dermatology, Drug efficacy, Drug indication, Drug mechanism, Drug safety, Eczema, Epidermodysplasia verruciformis, Epidermoid cyst, Erosion, Erythema, Fatigue, Febrile convulsion, Fever, Flu like syndrome, Granuloma annulare, Headache, Herpes simplex, Human, Immunostimulation, Kaposi sarcoma, Lichen (disease), Lichen planopilaris, Lichen planus, Lichen sclerosus et atrophicus, Lupus erythematosus, Malignant lentigo, Melanoma, Melanoma in situ, Molluscum contagiosum, Morphea, Myalgia, Mycosis fungoides, Nausea, Neuropathic pain, Nonhuman, Orf virus, Orthostatic hypotension, Paget skin disease, Pain, Pemphigus, Poliosis, Poxvirus infection, Pruritus, Psoriasis, Pustule, Randomized controlled trial (topic), Review, Side effect, Skin burning sensation, Skin cancer, Skin disease, Skin infection, Skin irritation, Skin leishmaniasis, Skin metastasis, Skin ulcer, Squamous cell carcinoma, Verruca vulgaris, Vitiligo