Osteoclast-Like Giant Cells: Focus on Entities Relevant to Dermatopathology and Underlying Pathogenesis
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Lippincott Williams and Wilkins
Abstract
Osteoclast-like giant cells (OLGCs) resemble osteoclasts with their abundant cytoplasm and well-developed organelles. OLGCs are characteristic features of giant cell tumor of the tendon sheath and giant cell tumor of soft tissue but they have also been described in numerous other cutaneous conditions. The diagnostic and prognostic significance of the presence of OLGCs is unknown. Here, we summarize the clinical entities that can exhibit these cells to avoid a histological overlap, affecting diagnosis and management. © 2021 Lippincott Williams and Wilkins. All rights reserved.
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Giant cells, Multinucleated cells, Osteoclast-like giant cells, Osteoclasts, Biopsy, Humans, Phenotype, Skin, Skin diseases, Denosumab, Zoledronic acid, Article, Cancer prognosis, Cell fusion, Clinical feature, Dermatofibroma, Giant cell tumor of tendon sheath, Histopathology, Human, Intradermal nevus, Juvenile xanthogranuloma, Langerhans cell histiocytosis, Melanoma, Metastasis, Multinuclear cell, Neoplasm, Nephrogenic systemic fibrosis, Nonhuman, Osteoclast, Osteosarcoma, Pathogenesis, Plexiform fibrohistiocytic tumor, Primary cutaneous carcinosarcoma, Skin disease, Soft tissue tumor, Squamous cell carcinoma, Systemic hyalinosis, Giant cell, Metabolism, Pathology