Osteoclast-Like Giant Cells: Focus on Entities Relevant to Dermatopathology and Underlying Pathogenesis

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dc.contributor.authorHamie, Lamiaa
dc.contributor.authorAbbas, Ossama M.
dc.contributor.authorKurban, Mazen S.
dc.contributor.authorBhawan, Jag
dc.contributor.departmentDermatology
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:40:49Z
dc.date.available2025-01-24T11:40:49Z
dc.date.issued2021
dc.description.abstractOsteoclast-like giant cells (OLGCs) resemble osteoclasts with their abundant cytoplasm and well-developed organelles. OLGCs are characteristic features of giant cell tumor of the tendon sheath and giant cell tumor of soft tissue but they have also been described in numerous other cutaneous conditions. The diagnostic and prognostic significance of the presence of OLGCs is unknown. Here, we summarize the clinical entities that can exhibit these cells to avoid a histological overlap, affecting diagnosis and management. © 2021 Lippincott Williams and Wilkins. All rights reserved.
dc.identifier.doihttps://doi.org/10.1097/DAD.0000000000001769
dc.identifier.eid2-s2.0-85101688051
dc.identifier.pmid33595228
dc.identifier.urihttp://hdl.handle.net/10938/29585
dc.language.isoen
dc.publisherLippincott Williams and Wilkins
dc.relation.ispartofAmerican Journal of Dermatopathology
dc.sourceScopus
dc.subjectGiant cells
dc.subjectMultinucleated cells
dc.subjectOsteoclast-like giant cells
dc.subjectOsteoclasts
dc.subjectBiopsy
dc.subjectHumans
dc.subjectPhenotype
dc.subjectSkin
dc.subjectSkin diseases
dc.subjectDenosumab
dc.subjectZoledronic acid
dc.subjectArticle
dc.subjectCancer prognosis
dc.subjectCell fusion
dc.subjectClinical feature
dc.subjectDermatofibroma
dc.subjectGiant cell tumor of tendon sheath
dc.subjectHistopathology
dc.subjectHuman
dc.subjectIntradermal nevus
dc.subjectJuvenile xanthogranuloma
dc.subjectLangerhans cell histiocytosis
dc.subjectMelanoma
dc.subjectMetastasis
dc.subjectMultinuclear cell
dc.subjectNeoplasm
dc.subjectNephrogenic systemic fibrosis
dc.subjectNonhuman
dc.subjectOsteoclast
dc.subjectOsteosarcoma
dc.subjectPathogenesis
dc.subjectPlexiform fibrohistiocytic tumor
dc.subjectPrimary cutaneous carcinosarcoma
dc.subjectSkin disease
dc.subjectSoft tissue tumor
dc.subjectSquamous cell carcinoma
dc.subjectSystemic hyalinosis
dc.subjectGiant cell
dc.subjectMetabolism
dc.subjectPathology
dc.titleOsteoclast-Like Giant Cells: Focus on Entities Relevant to Dermatopathology and Underlying Pathogenesis
dc.typeArticle

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