Novel carbocyclic nucleoside analogs suppress glomerular mesangial cells proliferation and matrix protein accumulation through ROS-dependent mechanism in the diabetic milieu. II. Acylhydrazone-functionalized pyrimidines

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dc.contributor.authorBouhadir, Kamal Hani
dc.contributor.authorKoubeissi, Ali
dc.contributor.authorMohsen, Fatima A.
dc.contributor.authorEl-Harakeh, Mira Diab
dc.contributor.authorCheaib, Rouba
dc.contributor.authorYounes, Joan
dc.contributor.authorAzzi, Georges
dc.contributor.authorEid, Assaad A.
dc.contributor.departmentDepartment of Chemistry
dc.contributor.departmentAnatomy, Cell Biology, and Physiological Sciences
dc.contributor.facultyFaculty of Arts and Sciences (FAS)
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:21:46Z
dc.date.available2025-01-24T11:21:46Z
dc.date.issued2016
dc.description.abstractWe report herein the synthesis of a novel series of carbocyclic acylhydrazone derivatives of uracil, thymine and cytosine from the corresponding nucleic bases and their biological activity to treat diabetic nephropathy. Intriguingly, five derivatives significantly reduced high-glucose induced glomerular mesangial cells proliferation and matrix protein accumulation in vitro. The anti-oxidative effects displayed by these molecules suggest that their activity might involve a ROS-dependent mechanism.
dc.identifier.doihttps://doi.org/10.1016/j.bmcl.2015.12.042
dc.identifier.eid2-s2.0-84979197259
dc.identifier.pmid26733477
dc.identifier.urihttp://hdl.handle.net/10938/25316
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofBioorganic and Medicinal Chemistry Letters
dc.sourceMedline
dc.subjectActins/metabolism
dc.subjectAnimals
dc.subjectCell proliferation/drug effects
dc.subjectCells, cultured
dc.subjectDiabetes mellitus, type 2/metabolism/pathology
dc.subjectFibronectins/metabolism
dc.subjectGlucose/pharmacology
dc.subjectMesangial cells/cytology/drug effects/metabolism
dc.subjectNucleosides/chemical synthesis/chemistry/pharmacology
dc.subjectPyrimidines/chemical synthesis/chemistry/pharmacology
dc.subjectRats
dc.subjectReactive oxygen species/metabolism
dc.subjectAcylhydrazones
dc.subjectCarbocyclic nucleosides
dc.subjectCytosine
dc.subjectDiabetic nephropathy
dc.subjectThymine
dc.subjectUracil
dc.titleNovel carbocyclic nucleoside analogs suppress glomerular mesangial cells proliferation and matrix protein accumulation through ROS-dependent mechanism in the diabetic milieu. II. Acylhydrazone-functionalized pyrimidines
dc.typeArticle

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