Brucellosis causing bone marrow aplasia in an 11-year-old patient with complete recovery after treatment
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Elsevier Ltd
Abstract
Brucellosis is one of the most prevalent zoonotic infections in the Middle East. The disease may present with a range of symptoms from a simple febrile illness to severe invasive infections affecting different organ systems (meningitis, osteomyelitis). In this paper we present an eleven-year-old girl who was diagnosed with “idiopathic bone marrow aplasia” and planned for hematopoietic stem cell transplant (HSCT), when pre-transplant work-up showed high brucella titers. The patient was started on doxycycline, rifampin and gentamicin initially, with discontinuation of the latter 3 weeks into therapy. She recovered completely after 8 months of treatment. © 2022
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Aplastic anemia, Brucellosis, Pancytopenia, Zoonotic infections, Alkaline phosphatase, Bilirubin, C reactive protein, Doxycycline, Gentamicin, Hepatitis b surface antigen, Immunoglobulin, Immunoglobulin g, Immunoglobulin m, Lactate dehydrogenase, Liver enzyme, Rifampicin, Rna 16s, Absolute neutrophil count, Anemia, Antimicrobial therapy, Article, Blood culture, Bone marrow aplasia, Bone marrow biopsy, Brucella melitensis, Case report, Child, Clinical article, Cytomegalovirus, Epstein barr virus, Erythrocyte sedimentation rate, Erythrocyte transfusion, Ferritin blood level, Hematopoietic stem cell transplantation, Hemoglobin blood level, Hepatitis c virus, Human, Human cell, Human immunodeficiency virus, Infection, Lebanese, Leukocyte count, Leukopenia, Male, Nonhuman, Nuclear magnetic resonance imaging, Physical examination, Platelet count, Reticulocyte, School child, Thrombocytopenia