Brucellosis causing bone marrow aplasia in an 11-year-old patient with complete recovery after treatment

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dc.contributor.authorYoussef, Nour J.
dc.contributor.authorYoussef, Yolla
dc.contributor.authorNoun, Dolly
dc.contributor.authorAbboud, Miguel Raul
dc.contributor.authorDbaibo, Ghassan S.
dc.contributor.departmentPediatrics and Adolescent Medicine
dc.contributor.departmentSpecialized Clinical Programs and Services
dc.contributor.departmentCenter for Infectious Diseases Research
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T12:11:20Z
dc.date.available2025-01-24T12:11:20Z
dc.date.issued2022
dc.description.abstractBrucellosis is one of the most prevalent zoonotic infections in the Middle East. The disease may present with a range of symptoms from a simple febrile illness to severe invasive infections affecting different organ systems (meningitis, osteomyelitis). In this paper we present an eleven-year-old girl who was diagnosed with “idiopathic bone marrow aplasia” and planned for hematopoietic stem cell transplant (HSCT), when pre-transplant work-up showed high brucella titers. The patient was started on doxycycline, rifampin and gentamicin initially, with discontinuation of the latter 3 weeks into therapy. She recovered completely after 8 months of treatment. © 2022
dc.identifier.doihttps://doi.org/10.1016/j.idcr.2022.e01531
dc.identifier.eid2-s2.0-85132530909
dc.identifier.urihttp://hdl.handle.net/10938/32542
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofIDCases
dc.sourceScopus
dc.subjectAplastic anemia
dc.subjectBrucellosis
dc.subjectPancytopenia
dc.subjectZoonotic infections
dc.subjectAlkaline phosphatase
dc.subjectBilirubin
dc.subjectC reactive protein
dc.subjectDoxycycline
dc.subjectGentamicin
dc.subjectHepatitis b surface antigen
dc.subjectImmunoglobulin
dc.subjectImmunoglobulin g
dc.subjectImmunoglobulin m
dc.subjectLactate dehydrogenase
dc.subjectLiver enzyme
dc.subjectRifampicin
dc.subjectRna 16s
dc.subjectAbsolute neutrophil count
dc.subjectAnemia
dc.subjectAntimicrobial therapy
dc.subjectArticle
dc.subjectBlood culture
dc.subjectBone marrow aplasia
dc.subjectBone marrow biopsy
dc.subjectBrucella melitensis
dc.subjectCase report
dc.subjectChild
dc.subjectClinical article
dc.subjectCytomegalovirus
dc.subjectEpstein barr virus
dc.subjectErythrocyte sedimentation rate
dc.subjectErythrocyte transfusion
dc.subjectFerritin blood level
dc.subjectHematopoietic stem cell transplantation
dc.subjectHemoglobin blood level
dc.subjectHepatitis c virus
dc.subjectHuman
dc.subjectHuman cell
dc.subjectHuman immunodeficiency virus
dc.subjectInfection
dc.subjectLebanese
dc.subjectLeukocyte count
dc.subjectLeukopenia
dc.subjectMale
dc.subjectNonhuman
dc.subjectNuclear magnetic resonance imaging
dc.subjectPhysical examination
dc.subjectPlatelet count
dc.subjectReticulocyte
dc.subjectSchool child
dc.subjectThrombocytopenia
dc.titleBrucellosis causing bone marrow aplasia in an 11-year-old patient with complete recovery after treatment
dc.typeArticle

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