Procalcitonin: Where Are We Now?
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W.B. Saunders
Abstract
Procalcitonin is a biomarker that is generally elevated in bacterial infections. This review describes a conceptual framework for biomarkers using lessons from the history of troponin, applies this framework to procalcitonin with a review of observational studies and randomized trials in and out of the intensive care unit, and concludes with clinical recommendations and thoughts on how to test a test. © 2019 Elsevier Inc.
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Keywords
Antibiotics, Mortality, Procalcitonin, Respiratory tract infection, Sepsis, Anti-bacterial agents, Biomarkers, Humans, Respiratory tract infections, Antibiotic agent, Antiinfective agent, Troponin, Biological marker, Chronic obstructive lung disease, Community acquired pneumonia, Conceptual framework, Critically ill patient, Evidence based medicine, History, Human, Intensive care unit, Peritonitis, Practice guideline, Prediction, Priority journal, Randomized controlled trial (topic), Review, Treatment outcome, Blood