Investigating the Association Between Obesity, Triglyceride Glucose Index, and Kidney Stones in a Lebanese Sample: Implications for a Kidney Stone Prevention Toolkit

Abstract

The triglyceride-glucose index (TyG) is a marker of insulin resistance (IR), which is associated with kidney stones. Additionally, obese patients tend to have IR; therefore, they are at an increased risk of developing kidney stones. This study examined the associations between obesity, the triglyceride-glucose index, and kidney stones. The findings revealed that body mass index (BMI) and smoking were highly associated with kidney stones at a univariate level. Additionally, age, geographical location, calcium levels, and estimated glomerular filtration rate (eGFR), demonstrated associations with kidney stones at both univariate and multivariate levels. Although previous literature suggests a link between triglyceride-glucose index and kidney stones, this study did not confirm the association due to the high percentage of missing data. These results highlight the importance of metabolic and demographic factors in kidney stone formation, warranting further research with more comprehensive datasets. We have proposed a kidney stone toolkit, based on our findings in the context of a sample from Lebanon.