Rheumatological complications of beta-thalassaemia: An overview
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Oxford University Press
Abstract
Beta-thalassaemia, an autosomal recessive haemoglobinopathy, ranks among the most frequent monogenetic diseases globally. The severe form of the disease, beta-thalassaemia major, is accompanied by progressive involvement of multiple organ systems as a result of the disease pathophysiology as well as iron overload from blood transfusions on a regular basis. Some of the manifestations might also be caused by medications used to manage iron overload. The purpose of this review is to highlight the rheumatological complications of beta-thalassaemia, which include musculoskeletal manifestations, such as arthritis and arthropathies, joint effusions, osteoporosis, bone fractures and myalgias, in addition to CTDs, such as pseudoxanthoma elasticum. Rheumatologists are strongly encouraged to take part in a multidisciplinary approach to the management of this debilitating disease. © The Author 2017.
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Keywords
Arthralgia, Arthritis, Aseptic necrosis of femoral head, Deferiprone-related arthropathy, Fractures, Iron overload, Joint effusion, Osteoporosis, Pseudoxanthoma elasticum, Thalassaemia, Beta-thalassemia, Blood transfusion, Connective tissue diseases, Femur head necrosis, Fractures, bone, Humans, Iron chelating agents, Joint diseases, Myalgia, Pyridones, Transfusion reaction, Deferiprone, Iron chelating agent, Pyridone derivative, Arthropathy, Aseptic necrosis, Beta thalassemia, Femoral head, Fracture, Hemoglobinopathy, Human, Necrosis, Pathophysiology, Review, Rheumatologist, Blood transfusion reaction, Chemically induced, Complication, Connective tissue disease