Rheumatological complications of beta-thalassaemia: An overview

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dc.contributor.authorNoureldine, Mohammad Hassan A.
dc.contributor.authorTaher, Ali T.
dc.contributor.authorHaydar, Ali A.
dc.contributor.authorBerjawi, Ahmad
dc.contributor.authorKhamashta, Munther A.
dc.contributor.authorUthman, Imad W.
dc.contributor.departmentInternal Medicine
dc.contributor.departmentDivision of Allergy, Immunology and Rheumatology
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:53:11Z
dc.date.available2025-01-24T11:53:11Z
dc.date.issued2018
dc.description.abstractBeta-thalassaemia, an autosomal recessive haemoglobinopathy, ranks among the most frequent monogenetic diseases globally. The severe form of the disease, beta-thalassaemia major, is accompanied by progressive involvement of multiple organ systems as a result of the disease pathophysiology as well as iron overload from blood transfusions on a regular basis. Some of the manifestations might also be caused by medications used to manage iron overload. The purpose of this review is to highlight the rheumatological complications of beta-thalassaemia, which include musculoskeletal manifestations, such as arthritis and arthropathies, joint effusions, osteoporosis, bone fractures and myalgias, in addition to CTDs, such as pseudoxanthoma elasticum. Rheumatologists are strongly encouraged to take part in a multidisciplinary approach to the management of this debilitating disease. © The Author 2017.
dc.identifier.doihttps://doi.org/10.1093/rheumatology/kex058
dc.identifier.eid2-s2.0-85039068091
dc.identifier.pmid28371817
dc.identifier.urihttp://hdl.handle.net/10938/31097
dc.language.isoen
dc.publisherOxford University Press
dc.relation.ispartofRheumatology (United Kingdom)
dc.sourceScopus
dc.subjectArthralgia
dc.subjectArthritis
dc.subjectAseptic necrosis of femoral head
dc.subjectDeferiprone-related arthropathy
dc.subjectFractures
dc.subjectIron overload
dc.subjectJoint effusion
dc.subjectOsteoporosis
dc.subjectPseudoxanthoma elasticum
dc.subjectThalassaemia
dc.subjectBeta-thalassemia
dc.subjectBlood transfusion
dc.subjectConnective tissue diseases
dc.subjectFemur head necrosis
dc.subjectFractures, bone
dc.subjectHumans
dc.subjectIron chelating agents
dc.subjectJoint diseases
dc.subjectMyalgia
dc.subjectPyridones
dc.subjectTransfusion reaction
dc.subjectDeferiprone
dc.subjectIron chelating agent
dc.subjectPyridone derivative
dc.subjectArthropathy
dc.subjectAseptic necrosis
dc.subjectBeta thalassemia
dc.subjectFemoral head
dc.subjectFracture
dc.subjectHemoglobinopathy
dc.subjectHuman
dc.subjectNecrosis
dc.subjectPathophysiology
dc.subjectReview
dc.subjectRheumatologist
dc.subjectBlood transfusion reaction
dc.subjectChemically induced
dc.subjectComplication
dc.subjectConnective tissue disease
dc.titleRheumatological complications of beta-thalassaemia: An overview
dc.typeReview

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