Flavonoids in adipose tissue inflammation and atherosclerosis: One arrow, two targets

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dc.contributor.authorFardoun, Manal Muin
dc.contributor.authorMaaliki, Dina S.
dc.contributor.authorHalabi, Nabil M.
dc.contributor.authorIratni, Rabah
dc.contributor.authorBitto, Alessandra
dc.contributor.authorBaydoun, Elias Abdel Hasan
dc.contributor.authorEid, Ali H.
dc.contributor.departmentDepartment of Biology
dc.contributor.departmentPharmacology and Toxicology
dc.contributor.facultyFaculty of Arts and Sciences (FAS)
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:20:55Z
dc.date.available2025-01-24T11:20:55Z
dc.date.issued2020
dc.description.abstractFlavonoids are polyphenolic compounds naturally occurring in fruits and vegetables, in addition to beverages such as tea and coffee. Flavonoids are emerging as potent therapeutic agents for cardiovascular as well as metabolic diseases. Several studies corroborated an inverse relationship between flavonoid consumption and cardiovascular disease (CVD) or adipose tissue inflammation (ATI). Flavonoids exert their anti-atherogenic effects by increasing nitric oxide (NO), reducing reactive oxygen species (ROS), and decreasing pro-inflammatory cytokines. In addition, flavonoids alleviate ATI by decreasing triglyceride and cholesterol levels, as well as by attenuating inflammatory mediators. Furthermore, flavonoids inhibit synthesis of fatty acids and promote their oxidation. In this review, we discuss the effect of the main classes of flavonoids, namely flavones, flavonols, flavanols, flavanones, anthocyanins, and isoflavones, on atherosclerosis and ATI. In addition, we dissect the underlying molecular and cellular mechanisms of action for these flavonoids. We conclude by supporting the potential benefit for flavonoids in the management or treatment of CVD; yet, we call for more robust clinical studies for safety and pharmacokinetic values. © 2020 The Author(s).
dc.identifier.doihttps://doi.org/10.1042/CS20200356
dc.identifier.eid2-s2.0-85086712200
dc.identifier.pmid32556180
dc.identifier.urihttp://hdl.handle.net/10938/25167
dc.language.isoen
dc.publisherPortland Press Ltd
dc.relation.ispartofClinical Science
dc.sourceScopus
dc.subjectAdipose tissue
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectAtherosclerosis
dc.subjectFlavonoids
dc.subjectHumans
dc.subjectInflammation
dc.subjectModels, biological
dc.subjectAnthocyanin
dc.subjectAurantiin
dc.subjectDaidzein
dc.subjectEpicatechin
dc.subjectEpigallocatechin gallate
dc.subjectFlavanol derivative
dc.subjectFlavanone derivative
dc.subjectFlavone derivative
dc.subjectFlavonoid
dc.subjectFlavonol derivative
dc.subjectGenistein
dc.subjectHesperetin
dc.subjectHesperidin
dc.subjectIsoflavone derivative
dc.subjectKaempferol
dc.subjectLuteolin
dc.subjectNaringenin
dc.subjectNobiletin
dc.subjectQuercetin
dc.subjectResveratrol
dc.subjectTangeretin
dc.subjectAntioxidant
dc.subjectAntiinflammatory activity
dc.subjectDiet supplementation
dc.subjectDrug efficacy
dc.subjectDrug mechanism
dc.subjectDrug safety
dc.subjectDrug targeting
dc.subjectEthnopharmacology
dc.subjectHeart protection
dc.subjectHerbal medicine
dc.subjectHuman
dc.subjectMeta analysis (topic)
dc.subjectNonhuman
dc.subjectPriority journal
dc.subjectReview
dc.subjectSoft tissue inflammation
dc.subjectAnimal
dc.subjectBiological model
dc.subjectChemistry
dc.subjectComplication
dc.subjectPathology
dc.titleFlavonoids in adipose tissue inflammation and atherosclerosis: One arrow, two targets
dc.typeReview

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