Hyper-CVAD combined with Venetoclax for relapsed pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN): A case report and literature review
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Elsevier Ltd
Abstract
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is a very rare type of leukemia in children, Although BPDCN is a chemo-sensitive tumor, the relapse rate is very high. Tagraxofusp, which is a CD123-directed cytotoxin has been used as a targeted therapy and has shown promising results in patients with either untreated or relapsed BPDCN. There is also a good response with Venetoclax, a selective BCL2 inhibitor, as a single agent or in combination with chemotherapy. Here, we described a case of a pediatric patient with BPDCN who was treated initially with ALL-based regimen followed by Allogeneic hematopoietic stem-cell transplantation (HSCT) and salvaged with Hyper-CVAD combined with Venetoclax after testicular relapse 11 months post Allogeneic HSCT. © 2022 The Authors
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Dendritic, Leukemia, Neoplasm, Plasmacytoid, Venetoclax, Asparaginase, Busulfan, Cd123 antigen, Cd16 antigen, Cd4 antigen, Cd56 antigen, Common acute lymphoblastic leukemia antigen, Cyclophosphamide, Cyclosporine, Cytarabine, Daunorubicin, Dexamethasone, Doxorubicin, Fludarabine, Hla dr antigen, Hydrocortisone, Methotrexate, Prednisone, Receptor type tyrosine protein phosphatase c, Tagraxofusp, Thiotepa, Thymocyte antibody, Vincristine, Abdominal pain, Allogeneic hematopoietic stem cell transplantation, Anemia, Article, Bacteremia, Blastic plasmacytoid dendritic cell neoplasm, Bone marrow biopsy, Cancer chemotherapy, Cancer recurrence, Case report, Child, Clinical article, Coronavirus disease 2019, Dendritic cell sarcoma, Drug dose reduction, Echography, Flow cytometry, Human, Human tissue, Immunohistochemistry, Male, Multiple cycle treatment, Multiplex polymerase chain reaction, Neutropenia, Platelet count, Positron emission tomography, Reciprocal chromosome translocation, Relapse, School child, Thrombocytopenia, Whole body radiation