Hematological manifestations of antiphospholipid syndrome: Going beyond thrombosis
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Date
Authors
El-Hasbani, Georges
Saliba, Antoine N.
Uthman, Imad W.
Taher, Ali T.
Journal Title
Journal ISSN
Volume Title
Publisher
Churchill Livingstone
Abstract
Thrombotic complications are a hallmark of antiphospholipid syndrome (APS). These vascular – arterial, venous, and/or small vessel – complications are well described and known to hematologists and healthcare providers caring for patients with this disease. In this review, we shed light on other hematological manifestations of the disease, including bleeding, thrombocytopenia, autoimmune hemolytic anemia, and thrombotic microangiopathy syndromes. While these manifestations are not bona fide clinical criteria for the diagnosis of APS, they frequently interact and contribute to the complexity of clinical management of APS. © 2022 Elsevier Ltd
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Keywords
Anemia, Antiphospholipid, Bleeding, Bone marrow diseases, Hemolysis, Thrombocytopenia, Anemia, hemolytic, autoimmune, Antiphospholipid syndrome, Cardiovascular diseases, Humans, Thrombosis, Anticoagulant agent, Liver enzyme, Autoimmune hemolytic anemia, Autoimmune thrombocytopenia, B12 deficiency, Hellp syndrome, Hematological procedure, Hemolytic uremic syndrome, Heparin induced thrombocytopenia, Human, Hypoprothrombinemia, Iron deficiency, Leukemia, Myelofibrosis, Pathophysiology, Review, Thrombotic microangiopathy, Thrombotic thrombocytopenic purpura, Cardiovascular disease, Complication