Striving to cure adult T-cell leukaemia/lymphoma: A role for allogeneic stem cell transplant
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Nature Publishing Group
Abstract
Adult T-cell leukaemia/lymphoma (ATL) is an aggressive HTLV-1-related malignancy, rare outside of regions where the retrovirus is endemic. Although the use of antiviral therapy has improved outcomes, particularly for indolent forms of ATL, response to combination chemotherapy is poor and outcomes for aggressive subtypes remains dismal. Consolidation with allogeneic stem cell transplant (alloSCT) has an increasing role in the management of ATL in eligible patients, offering favourable long-term remission rates. However, relatively high-transplant-related mortality and issues with donor recruitment for certain ethnicities remain problematic. In this review, we discuss the rationale for and issues surrounding alloSCT in ATL in the context of conventional and emerging therapies. © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
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Adult, Combined modality therapy, Human t-lymphotropic virus 1, Humans, Leukemia-lymphoma, adult t-cell, Stem cell transplantation, Treatment outcome, Alemtuzumab, Arsenic trioxide, Bortezomib, Daclizumab, Lenalidomide, Mogamulizumab, Recombinant alpha interferon, Zidovudine, Allogeneic stem cell transplantation, Antiviral therapy, Autologous hematopoietic stem cell transplantation, Cancer chemotherapy, Cancer prognosis, Cord blood stem cell transplantation, Cytomegalovirus infection, Donor selection, Engraftment, Graft failure, Graft recipient, Graft versus host reaction, Graft versus leukemia effect, Htlv-1 infection, Human, Immunosuppressive treatment, Infectious complication, Maintenance chemotherapy, Minimal residual disease, Outcome assessment, Overall survival, Phase 2 clinical trial (topic), Phase 3 clinical trial (topic), Priority journal, Progression free survival, Randomized controlled trial (topic), Review, Survival time, T cell depletion, T cell leukemia, Transplantation conditioning, Treatment response, Viral clearance, Drug effects, Mortality, Multimodality cancer therapy, Procedures