How I manage medical complications of b-thalassemia in adults
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American Society of Hematology
Abstract
The complex pathophysiology in b-thalassemia can translate to multiple morbidities that affect every organ system. Improved survival due to advances in management means that patients are exposed to the harmful effects of ineffective erythropoiesis, anemia, and iron overload for a longer duration, and we started seeing new or more frequent complications in adult compared with younger patients. In this article, we highlight particular aspects of managing adult patients with b-thalassemia, using our own experience in treating such patients. We cover both transfusion-dependent and nontransfusion-dependent forms of the disease and tackle specific morbidities of highest interest. © 2018 by The American Society of Hematology.
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Adult, Arrhythmias, cardiac, Beta-thalassemia, Carcinoma, hepatocellular, Female, Humans, Hypertension, pulmonary, Liver neoplasms, Male, Middle aged, Venous thrombosis, Amiodarone, Antiarrhythmic agent, Beta adrenergic receptor blocking agent, Deferasirox, Deferiprone, Deferoxamine, Glecaprevir plus pibrentasvir, Interferon, Ledipasvir plus sofosbuvir, Peginterferon, Ribavirin, Sildenafil, Anemia, Article, Beta thalassemia, Blood transfusion, Erythropoiesis, Groups by age, Heart arrhythmia, Heart catheterization, Hepatitis c, Human, Hypercoagulability, Iron chelation, Iron intake, Iron overload, Lifestyle modification, Liver cirrhosis, Liver disease, Morbidity, Pathophysiology, Priority journal, Pulmonary hypertension, Risk factor, Splenectomy, Splenomegaly, Survival, Thrombosis, Case report, Complication, Liver cell carcinoma, Liver tumor, Vein thrombosis