How I manage medical complications of b-thalassemia in adults

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dc.contributor.authorTaher, Ali T.
dc.contributor.authorCappellini, Maria Teresa
dc.contributor.departmentInternal Medicine
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:53:30Z
dc.date.available2025-01-24T11:53:30Z
dc.date.issued2018
dc.description.abstractThe complex pathophysiology in b-thalassemia can translate to multiple morbidities that affect every organ system. Improved survival due to advances in management means that patients are exposed to the harmful effects of ineffective erythropoiesis, anemia, and iron overload for a longer duration, and we started seeing new or more frequent complications in adult compared with younger patients. In this article, we highlight particular aspects of managing adult patients with b-thalassemia, using our own experience in treating such patients. We cover both transfusion-dependent and nontransfusion-dependent forms of the disease and tackle specific morbidities of highest interest. © 2018 by The American Society of Hematology.
dc.identifier.doihttps://doi.org/10.1182/blood-2018-06-818187
dc.identifier.eid2-s2.0-85055612554
dc.identifier.pmid30206117
dc.identifier.urihttp://hdl.handle.net/10938/31113
dc.language.isoen
dc.publisherAmerican Society of Hematology
dc.relation.ispartofBlood
dc.sourceScopus
dc.subjectAdult
dc.subjectArrhythmias, cardiac
dc.subjectBeta-thalassemia
dc.subjectCarcinoma, hepatocellular
dc.subjectFemale
dc.subjectHumans
dc.subjectHypertension, pulmonary
dc.subjectLiver neoplasms
dc.subjectMale
dc.subjectMiddle aged
dc.subjectVenous thrombosis
dc.subjectAmiodarone
dc.subjectAntiarrhythmic agent
dc.subjectBeta adrenergic receptor blocking agent
dc.subjectDeferasirox
dc.subjectDeferiprone
dc.subjectDeferoxamine
dc.subjectGlecaprevir plus pibrentasvir
dc.subjectInterferon
dc.subjectLedipasvir plus sofosbuvir
dc.subjectPeginterferon
dc.subjectRibavirin
dc.subjectSildenafil
dc.subjectAnemia
dc.subjectArticle
dc.subjectBeta thalassemia
dc.subjectBlood transfusion
dc.subjectErythropoiesis
dc.subjectGroups by age
dc.subjectHeart arrhythmia
dc.subjectHeart catheterization
dc.subjectHepatitis c
dc.subjectHuman
dc.subjectHypercoagulability
dc.subjectIron chelation
dc.subjectIron intake
dc.subjectIron overload
dc.subjectLifestyle modification
dc.subjectLiver cirrhosis
dc.subjectLiver disease
dc.subjectMorbidity
dc.subjectPathophysiology
dc.subjectPriority journal
dc.subjectPulmonary hypertension
dc.subjectRisk factor
dc.subjectSplenectomy
dc.subjectSplenomegaly
dc.subjectSurvival
dc.subjectThrombosis
dc.subjectCase report
dc.subjectComplication
dc.subjectLiver cell carcinoma
dc.subjectLiver tumor
dc.subjectVein thrombosis
dc.titleHow I manage medical complications of b-thalassemia in adults
dc.typeArticle

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