Quantitative cancer risk assessment and local mortality burden for ambient air pollution in an eastern Mediterranean City

dc.contributor.authorDhaini, Hassan R.
dc.contributor.authorSalameh, Thérèse
dc.contributor.authorWaked, Antoine
dc.contributor.authorSauvage, Stéphane
dc.contributor.authorBorbon, Agnès
dc.contributor.authorFormenti, Paola
dc.contributor.authorDoussin, Jean François
dc.contributor.authorLocoge, Nadine
dc.contributor.authorAfif, Charbel
dc.contributor.departmentEnvironmental Health (ENHL)
dc.contributor.facultyFaculty of Health Sciences (FHS)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:34:18Z
dc.date.available2025-01-24T11:34:18Z
dc.date.issued2017
dc.description.abstractHealth risks posed by ambient air pollutants to the urban Lebanese population have not been well characterized. The aim of this study is to assess cancer risk and mortality burden of non-methane hydrocarbons (NMHCs) and particulates (PM) based on two field-sampling campaigns conducted during summer and winter seasons in Beirut. Seventy NMHCs were analyzed by TD-GC-FID. PM2.5 elemental carbon (EC) components were examined using a Lab OC-EC aerosol Analyzer, and polycyclic aromatic hydrocarbons were analyzed by GC-MS. The US EPA fraction-based approach was used to assess non-cancer hazard and cancer risk for the hydrocarbon mixture, and the UK Committee on Medical Effects of Air Pollutants (COMEAP) guidelines were followed to determine the PM2.5 attributable mortality burden. The average cumulative cancer risk exceeded the US EPA acceptable level (10−6) by 40-fold in the summer and 30-fold in the winter. Benzene was found to be the highest contributor to cancer risk (39–43%), followed by 1,3-butadiene (25–29%), both originating from traffic gasoline evaporation and combustion. The EC attributable average mortality fraction was 7.8–10%, while the average attributable number of deaths (AD) and years of life lost (YLL) were found to be 257–327 and 3086–3923, respectively. Our findings provide a baseline for future air monitoring programs, and for interventions aiming at reducing cancer risk in this population. © 2017, Springer-Verlag Berlin Heidelberg.
dc.identifier.doihttps://doi.org/10.1007/s11356-017-9000-y
dc.identifier.eid2-s2.0-85017503659
dc.identifier.pmid28417329
dc.identifier.urihttp://hdl.handle.net/10938/28039
dc.language.isoen
dc.publisherSpringer Verlag
dc.relation.ispartofEnvironmental Science and Pollution Research
dc.sourceScopus
dc.subjectAir pollution
dc.subjectCancer risk
dc.subjectLebanon
dc.subjectMortality burden
dc.subjectNmhc
dc.subjectParticulate matter
dc.subjectAir pollutants
dc.subjectBenzene
dc.subjectCities
dc.subjectEnvironmental monitoring
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectRisk assessment
dc.subjectVehicle emissions
dc.subjectBeirut
dc.subjectBeyrouth
dc.subjectMediterranean region
dc.subjectAerosol
dc.subjectAmbient air
dc.subjectAnalytical method
dc.subjectAtmospheric pollution
dc.subjectCancer
dc.subjectConcentration (composition)
dc.subjectElemental carbon
dc.subjectGuideline
dc.subjectHealth risk
dc.subjectMortality
dc.subjectNonmethane hydrocarbon
dc.subjectPah
dc.subjectQuantitative analysis
dc.subjectSeasonal variation
dc.subjectUrban pollution
dc.subjectAir pollutant
dc.subjectCity
dc.subjectExhaust gas
dc.subjectHuman
dc.subjectNeoplasm
dc.subjectToxicity
dc.titleQuantitative cancer risk assessment and local mortality burden for ambient air pollution in an eastern Mediterranean City
dc.typeArticle

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