Review of current guidelines for recurrent pregnancy loss: new strategies for optimal evaluation of women who may be superfertile

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dc.contributor.authorKhalife, Dalia
dc.contributor.authorGhazeeri, Ghina S.
dc.contributor.authorKutteh, William Hannah
dc.contributor.departmentObstetrics and Gynecology
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T12:08:03Z
dc.date.available2025-01-24T12:08:03Z
dc.date.issued2019
dc.description.abstractThe current evidence-based guidelines for the evaluation of recurrent pregnancy loss recommended by the American Society for Reproductive Medicine and by the European Society of Human Reproduction and Embryology are compared and contrasted in this review. The clinical use of either of these guidelines will result in a probable diagnosis for only half of the affected patients. New strategies for a full evaluation of recurrent pregnancy loss incorporating 24- chromosome microarary on the products of conception offer more explanations for patients and caregivers. This new algorithm should decrease the use of empiric, unproven treatments. Combining the results of genetic testing on the miscarriage tissue with the conventional diagnostic tests has made it possible to explain the etiology of pregnancy loss in more than 90% of the cases. This cost-saving strategy can decrease the emotional distress and frustration for both couples and physicians when it comes to management of recurrent pregnancy loss. © 2018
dc.identifier.doihttps://doi.org/10.1053/j.semperi.2018.12.008
dc.identifier.eid2-s2.0-85059771570
dc.identifier.pmid30642578
dc.identifier.urihttp://hdl.handle.net/10938/31693
dc.language.isoen
dc.publisherW.B. Saunders
dc.relation.ispartofSeminars in Perinatology
dc.sourceScopus
dc.subjectAbortion, habitual
dc.subjectFemale
dc.subjectFertility
dc.subjectGenetic testing
dc.subjectHumans
dc.subjectKiller cells, natural
dc.subjectPractice guidelines as topic
dc.subjectPregnancy
dc.subjectAcetylsalicylic acid
dc.subjectAntibiotic agent
dc.subjectBromocriptine
dc.subjectCabergoline
dc.subjectDoxycycline
dc.subjectGestagen
dc.subjectHeparin
dc.subjectLevothyroxine
dc.subjectLow molecular weight heparin
dc.subjectMetformin
dc.subjectAntiphospholipid syndrome
dc.subjectChromosome aberration
dc.subjectDiabetes mellitus
dc.subjectDisorders of carbohydrate metabolism
dc.subjectDna fragmentation
dc.subjectEndometrium
dc.subjectFluorescence in situ hybridization
dc.subjectGenetic counseling
dc.subjectGenetic screening
dc.subjectHuman
dc.subjectHyperprolactinemia
dc.subjectHypothyroidism
dc.subjectInfection
dc.subjectIntrauterine infection
dc.subjectLifestyle
dc.subjectLow drug dose
dc.subjectLuteal insufficiency
dc.subjectOvarian reserve
dc.subjectPractice guideline
dc.subjectPreimplantation genetic diagnosis
dc.subjectPriority journal
dc.subjectPsychological aspect
dc.subjectRecurrent pregnancy loss
dc.subjectReview
dc.subjectSpontaneous abortion
dc.subjectThrombophilia
dc.subjectThyroid disease
dc.subjectUterus malformation
dc.subjectVitamin d deficiency
dc.subjectImmunology
dc.subjectNatural killer cell
dc.subjectPhysiology
dc.subjectRecurrent abortion
dc.titleReview of current guidelines for recurrent pregnancy loss: new strategies for optimal evaluation of women who may be superfertile
dc.typeReview

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