Elastophagocytosis: Underlying mechanisms and associated cutaneous entities
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Mosby Inc.
Abstract
Elastophagocytosis is the phagocytosis of elastic fibers that can microscopically be seen in the cytoplasm of histiocytes, multinucleated giant cells, or both. Generally believed to be a characteristic feature of certain granulomatous disorders such as annular elastolytic giant cell granuloma or elastolytic disorders such as mid-dermal elastolysis, this feature has also been described in other cutaneous inflammatory conditions, cutaneous malignancies, infectious entities, and secondary to certain medications. The list of diseases that can exhibit this peculiar finding on histopathology is long. In this review we attempt to shed light on the available literature concerning the pathogenesis of this phenomenon and the plethora of skin conditions that exhibit elastophagocytosis. © 2014 by the American Academy of Dermatology, Inc.
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Elastolysis, Elastophagocytosis, Diagnosis, differential, Elastic tissue, Granuloma annulare, Granuloma, giant cell, Histiocytes, Humans, Lymphoma, t-cell, cutaneous, Mycosis fungoides, Phagocytosis, Skin diseases, Macrophage elastase, Nicorandil, Penicillamine, Acute febrile neutrophilic dermatosis, Anetoderma, Copper metabolism, Cutis laxa, Drug induced disease, Drug induced elastophagocytosis, Elastic fiber, Elastosis, Extracellular matrix, Fibroxanthoma, Giant cell granuloma, Granulomatosis mycosis fungoides, Granulomatous slack skin disease, Human, Lichen sclerosus et atrophicus, Linear focal elastosis, Macrophage, Monoclonal immunoglobulinemia, Pathogenesis, Priority journal, Protein expression, Pseudoxanthoma elasticum, Review, Sarcoidosis, Skin disease, Skin infection, Sun exposure, Transmission electron microscopy, Tumor associated elastophagocytosis