Intravenous clomipramine for treatment-resistant obsessive-compulsive disorder
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Oxford University Press
Abstract
Background: This open trial was conducted to evaluate the effectiveness of intravenous clomipramine (CMI) in refractory obsessive-compulsive disorder (OCD). Methods: Thirty OCD poor responders to previous multiple trials of anti-obsessive medications were selected and admitted to the hospital. Severity of the illness and response to treatment were primarily assessed by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). CMI was gradually administered intravenously for one week. All patients were thereafter switched to oral CMI with a maximum dose of 225 mg/day. Results: The Y-BOCS total score mean at admission was in the severe range (24-31), and dropped on discharge and followups to the moderate range (16-23). At discharge, 23 patients (76.7%) had a decrease in Y-BOCS =25% and were considered responders, while only 18 (60%) were still responders at 24 weeks. No relevant persistent side effects were reported. Conclusion: Intravenous clomipramine could be of benefit for severe OCD cases that have not adequately responded to several therapies, including oral clomipramine. © The Author 2016.
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Clomipramine, Intravenous clomipramine, Obsessive-compulsive disorder, Treatment-resistant ocd, Administration, intravenous, Adolescent, Adult, Female, Follow-up studies, Humans, Male, Middle aged, Serotonin uptake inhibitors, Treatment outcome, Young adult, Alprazolam, Lorazepam, Serotonin uptake inhibitor, Article, Clinical article, Controlled clinical trial, Controlled study, Disease severity, Drug efficacy, Follow up, General condition improvement, Hospital admission, Hospital discharge, Human, Low drug dose, Obsessive compulsive disorder, Open study, Patient selection, Priority journal, Treatment duration, Treatment response, Yale brown obsessive compulsive scale, Clinical trial, Intravenous drug administration, Psychology