Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: A new classification from the European Society for Blood and Marrow Transplantation
Loading...
Date
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Publishing Group
Abstract
Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation. © 2016 Macmillan Publishers Limited.
Description
Keywords
Adult, Biomarkers, Early diagnosis, Hematopoietic stem cell transplantation, Hepatic veno-occlusive disease, Humans, Risk factors, Sensitivity and specificity, Severity of illness index, Antithrombin iii, Bilirubin, Blood clotting factor 7, Busulfan, Cyclophosphamide, Cyclosporin, Defibrotide, Methotrexate, Norethisterone, Plasminogen activator inhibitor 1, Protein c, Rapamycin, Tacrolimus, Von willebrand factor, Biological marker, Allogeneic hematopoietic stem cell transplantation, Article, Ascites, Autologous hematopoietic stem cell transplantation, Diagnostic imaging, Differential diagnosis, Disease severity, Drug megadose, Genital bleeding, Graft versus host reaction, Hepatomegaly, Heredity, Hla matching, Human, Hyperbilirubinemia, Iron overload, Karnofsky performance status, Kidney failure, Liver dysfunction, Liver venoocclusive disease, Mortality rate, Multiple organ failure, Myeloablative conditioning, Portal hypertension, Priority journal, Prognosis, Reduced intensity conditioning, T cell depletion, Thrombocytopenia, Weight gain, Whole body radiation, Liver vein obstruction, Risk factor