Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: A new classification from the European Society for Blood and Marrow Transplantation

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dc.contributor.authorMohty, Mohamad
dc.contributor.authorMalard, Florent
dc.contributor.authorAbecassis, Manuel
dc.contributor.authorAerts, Erik
dc.contributor.authorAlaskar, Ahmed S.
dc.contributor.authorAljurf, Mahmoud Deeb
dc.contributor.authorArat, Mutlu Ersöz
dc.contributor.authorBader, Peter
dc.contributor.authorBaron, Frédéric A.
dc.contributor.authorBazarbachi, Ali Abdul Hamid
dc.contributor.authorBlaise, Didier P.
dc.contributor.authorCiceri, Fabio
dc.contributor.authorCorbacioglu, Selim
dc.contributor.authorDalle, Jean Hugues H.
dc.contributor.authorDignan, Fiona L.
dc.contributor.authorFukuda, Takahiro
dc.contributor.authorHuynh, Anne
dc.contributor.authorMasszi, Tamás
dc.contributor.authorMichallet, Mauricette C.
dc.contributor.authorNagler, Arnon
dc.contributor.authorNíChonghaile, Mairéad
dc.contributor.authorOkamoto, Syuuichirou ichiro
dc.contributor.authorPagliuca, Antonio
dc.contributor.authorPeters, Christina
dc.contributor.authorPetersen, Finn Bo
dc.contributor.authorRichardson, Paul Gerard
dc.contributor.authorRuutu, Tapani
dc.contributor.authorSavani, Bipin N.
dc.contributor.authorWallhult, Elisabeth
dc.contributor.authorYakoub-Agha, Ibrahim
dc.contributor.authorDuarte, Rafael F.
dc.contributor.authorCarreras, Enric
dc.contributor.departmentInternal Medicine
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:48:29Z
dc.date.available2025-01-24T11:48:29Z
dc.date.issued2016
dc.description.abstractSinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation. © 2016 Macmillan Publishers Limited.
dc.identifier.doihttps://doi.org/10.1038/bmt.2016.130
dc.identifier.eid2-s2.0-84968571756
dc.identifier.pmid27183098
dc.identifier.urihttp://hdl.handle.net/10938/30819
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.ispartofBone Marrow Transplantation
dc.sourceScopus
dc.subjectAdult
dc.subjectBiomarkers
dc.subjectEarly diagnosis
dc.subjectHematopoietic stem cell transplantation
dc.subjectHepatic veno-occlusive disease
dc.subjectHumans
dc.subjectRisk factors
dc.subjectSensitivity and specificity
dc.subjectSeverity of illness index
dc.subjectAntithrombin iii
dc.subjectBilirubin
dc.subjectBlood clotting factor 7
dc.subjectBusulfan
dc.subjectCyclophosphamide
dc.subjectCyclosporin
dc.subjectDefibrotide
dc.subjectMethotrexate
dc.subjectNorethisterone
dc.subjectPlasminogen activator inhibitor 1
dc.subjectProtein c
dc.subjectRapamycin
dc.subjectTacrolimus
dc.subjectVon willebrand factor
dc.subjectBiological marker
dc.subjectAllogeneic hematopoietic stem cell transplantation
dc.subjectArticle
dc.subjectAscites
dc.subjectAutologous hematopoietic stem cell transplantation
dc.subjectDiagnostic imaging
dc.subjectDifferential diagnosis
dc.subjectDisease severity
dc.subjectDrug megadose
dc.subjectGenital bleeding
dc.subjectGraft versus host reaction
dc.subjectHepatomegaly
dc.subjectHeredity
dc.subjectHla matching
dc.subjectHuman
dc.subjectHyperbilirubinemia
dc.subjectIron overload
dc.subjectKarnofsky performance status
dc.subjectKidney failure
dc.subjectLiver dysfunction
dc.subjectLiver venoocclusive disease
dc.subjectMortality rate
dc.subjectMultiple organ failure
dc.subjectMyeloablative conditioning
dc.subjectPortal hypertension
dc.subjectPriority journal
dc.subjectPrognosis
dc.subjectReduced intensity conditioning
dc.subjectT cell depletion
dc.subjectThrombocytopenia
dc.subjectWeight gain
dc.subjectWhole body radiation
dc.subjectLiver vein obstruction
dc.subjectRisk factor
dc.titleRevised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: A new classification from the European Society for Blood and Marrow Transplantation
dc.typeArticle

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